Human T-lymphotropic virus 1 infectious disease
MONDO:0005801A viral infectious disease that results in increased proliferation of affected CD4 lymphocytes, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, transmitted by contaminated needles used by intravenous-drug users, and transmitted by breast feeding. The person infected with HTLV-1 eventually develop an often rapidly fatal leukemia, while others will develop a debilitative myelopathy, uveitis, infectious dermatitis, or another inflammatory disorder.
Also known as: Human T-lymphotropic virus 1 caused disease or disorder, Human T-lymphotropic virus 1 disease or disorder, Human T-lymphotropic virus 1 infectious disease, human T-lymphotropic virus 1 infectious disease, HTLV-1, Human T lymphotropic virus type 1
37 clinical trials for this condition and its sub-types, 5 tagged with Human T-lymphotropic virus 1 infectious disease itself.
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Browse by category →Sub-types of Human T-lymphotropic virus 1 infectious disease
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Adult T-cell leukemia/lymphoma 31 trials
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Tropical spastic paraparesis 3 trials
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Experimental combo targets rare leukemia
Disease control Recruiting nowThis early-stage trial tests adding lenalidomide to standard chemotherapy (EPOCH) for adult T-cell leukemia-lymphoma, a rare and aggressive blood cancer linked to HTLV-1 infection. The main goal is to find the safest dose of lenalidomide when used with chemo. Up to 30 adults with…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Can a two-drug combo beat the HTLV-1 virus?
Disease control Recruiting nowThis Phase 2 trial compares the drug dolutegravir alone versus dolutegravir combined with tenofovir in 146 adults with HTLV-1 infection and related symptoms. The main goal is to see if the combination lowers the virus level more effectively and improves pain, spasticity, and musc…
Phase 2 • Sponsor: Carlos Brites • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Scientists seek tissue samples to unlock HIV and cancer mysteries
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists launch Long-Term study to unravel rare spinal disease caused by a virus
Knowledge-focused Recruiting nowThis study follows people infected with HTLV-I virus, some of whom develop a rare spinal cord condition called HAM/TSP. Researchers will track changes in symptoms, immune system markers, and virus levels over time. The goal is to better understand why only a few infected people g…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC