Hereditary hyperbilirubinemia

This study tests whether adding the drug vorinostat to standard care can prevent graft-versus-host disease (GVHD) in children and young adults (ages 1-26) with non-cancerous blood disorders who are getting a bone marrow transplant. GVHD is a serious complication where donor cells…

This trial tests whether using higher (less strict) bilirubin thresholds for starting light therapy in very preterm infants (born before 30 weeks) is as safe as the current Dutch guidelines. About 680 babies across Dutch NICUs will be randomly assigned to one of two threshold str…

This trial will test an artificial intelligence system designed to interpret routine newborn screening tests for inherited metabolic disorders. Researchers will compare the AI's accuracy to standard manual review by trained staff. The study plans to include 200,000 newborns in Ch…

This study tests whether the BIND score, a quick neurological check, can predict brain risk in newborns with severe jaundice. Researchers will use the score to guide phototherapy treatment in 80 infants under 28 days old. The goal is to catch and treat dangerous jaundice early, p…

This study looks at whether foot reflexology and body massage can help newborns with jaundice who are already receiving light therapy (phototherapy). Researchers will measure bilirubin levels, heart rate, breathing, and stress in 105 babies. The goal is to see if these gentle, dr…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …