Heart valve disorder
MONDO:0002869A disease involving the cardial valve.
Also known as: cardial valve disease, cardial valve disease or disorder, disease of cardial valve, disease or disorder of cardial valve, disorder of cardial valve, disorder of heart valve, heart valve disorder, valvular heart disorder
771 clinical trials for this condition and its sub-types, 181 tagged with Heart valve disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Heart valve disorder
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Aortic valve disorder 77 trials · 398 incl. sub-types
5 sub-types
- Aortic valve stenosis 319 trials · 322 incl. sub-types Sub-types →
- Aortic valve insufficiency 56 trials Sub-types →
- Familial bicuspid aortic valve 6 trials · 21 incl. sub-types Sub-types →
- Aortic valve calcification 14 trials
- Aortic valve prolapse 0 trials
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Mitral valve disorder 48 trials · 198 incl. sub-types
7 sub-types
- Mitral valve insufficiency 160 trials Sub-types →
- Mitral valve stenosis 26 trials Sub-types →
- Mitral valve prolapse 12 trials · 13 incl. sub-types Sub-types →
- Inherited mitral valve disease 0 trials · 1 incl. sub-types Sub-types →
- Rheumatic disease of mitral valve 1 trial
- Congenital anomaly of the mitral subvalvular apparatus 0 trials
- Mitral atresia disorder 0 trials
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Tricuspid valve disorder 25 trials · 94 incl. sub-types
4 sub-types
- Tricuspid valve insufficiency 83 trials
- Congenital tricuspid malformation 0 trials · 2 incl. sub-types Sub-types →
- Tricuspid valve stenosis 2 trials
- Cleft leaflet of tricuspid valve 0 trials
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Pulmonary valve disorder 3 trials · 26 incl. sub-types
3 sub-types
- Pulmonary valve insufficiency 19 trials
- Pulmonary valve stenosis 14 trials Sub-types →
- Rheumatic pulmonary valve disease 0 trials
Most studied deeper sub-types
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Can a less invasive valve replacement tame a failing aortic valve?
Disease control Stopped earlyThis study is a patient registry that collects information on people with severe aortic stenosis or aortic regurgitation who are treated with the Trilogy heart valve system, a device implanted via a catheter (TAVI) to replace the aortic valve without open-heart surgery. The goal …
Sponsor: JenaValve Technology, Inc. • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Clotting drug may replace plasma transfusions in heart surgery
Disease control Stopped earlyThis study compared two treatments to reduce bleeding after heart valve surgery: a concentrated clotting drug (PCC) versus fresh frozen plasma (FFP). The trial planned to enroll 476 adults undergoing elective valve surgery. It was terminated early, so the full comparison was not …
Phase 4 • Sponsor: SHI Jia • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Epilepsy drug may protect organs during heart surgery — trial tests the idea
Prevention Stopped earlyThis trial tests whether sodium valproate, a drug used for epilepsy, can reduce damage to the heart and kidneys in adults undergoing heart surgery with a heart-lung machine. Participants receive the drug for one to six weeks before their operation, and researchers measure organ i…
Phase 1/2 • Sponsor: University of Leicester • Aim: Prevention
Last updated Aug 19, 2026 00:00 UTC
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Heart surgery recovery: can patients manage their own precautions?
Symptom relief Stopped earlyThis study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…
Sponsor: University of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC