Head and neck carcinoma
MONDO:0002038A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Also known as: carcinoma of craniocervical region, carcinoma of head and neck, carcinoma of neck, carcinoma of the head and neck, craniocervical region carcinoma, head and neck carcinoma, neck carcinoma, carcinoma of the neck
4132 clinical trials for this condition and its sub-types, 73 tagged with Head and neck carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Head and neck carcinoma
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Head and neck squamous cell carcinoma 829 trials · 1,053 incl. sub-types
13 sub-types
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Lip and oral cavity squamous cell carcinoma 21 trials · 157 incl. sub-types Sub-types →
- Laryngeal squamous cell carcinoma 72 trials · 77 incl. sub-types Sub-types →
- Nasal cavity and paranasal sinus squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Nasopharyngeal squamous cell carcinoma 12 trials
- Paranasal sinus squamous cell carcinoma 11 trials Sub-types →
- Nasal cavity squamous cell carcinoma 6 trials
- External ear squamous cell carcinoma 1 trial
- Conjunctival squamous cell carcinoma 0 trials
- Cornea squamous cell carcinoma 0 trials
- Lacrimal gland squamous cell carcinoma 0 trials
- Middle ear squamous cell carcinoma 0 trials
- Primary intraosseous squamous cell carcinoma 0 trials
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Lip and oral cavity carcinoma 94 trials · 258 incl. sub-types
2 sub-types
- Oral cavity carcinoma 16 trials · 200 incl. sub-types Sub-types →
- Lip and oral cavity squamous cell carcinoma 21 trials · 157 incl. sub-types Sub-types →
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Oropharyngeal carcinoma 99 trials · 242 incl. sub-types
6 sub-types
- Oropharynx squamous cell carcinoma 192 trials · 195 incl. sub-types Sub-types →
- Tonsil carcinoma 1 trial · 5 incl. sub-types Sub-types →
- Carcinoma in situ of oropharynx 1 trial Sub-types →
- Carcinoma of soft palate 1 trial
- Adenoid cystic carcinoma of oropharynx 0 trials
- Epiglottis cancer 0 trials Sub-types →
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Nasopharyngeal carcinoma 210 trials · 211 incl. sub-types
2 sub-types
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Hypopharyngeal carcinoma 35 trials · 86 incl. sub-types
3 sub-types
- Hypopharynx squamous cell carcinoma 65 trials
- Carcinoma in situ of hypopharynx 2 trials Sub-types →
- Epiglottis cancer 0 trials Sub-types →
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Nasal cavity and paranasal sinus carcinoma 21 trials · 44 incl. sub-types
2 sub-types
- Paranasal sinus carcinoma 4 trials · 21 incl. sub-types Sub-types →
- Nasal cavity and paranasal sinus squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
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Nasal cavity carcinoma 3 trials · 9 incl. sub-types
4 sub-types
- Nasal cavity squamous cell carcinoma 6 trials
- Nasal cavity adenocarcinoma 1 trial
- Carcinoma arising in nasal papillomatosis 0 trials
- Nasal cavity carcinoma in situ 0 trials
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Eye carcinoma 0 trials · 5 incl. sub-types
9 sub-types
- PAX6-related ocular dysgenesis 0 trials · 2 incl. sub-types Sub-types →
- Eyelid carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Ocular sebaceous carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Aniridia 2 0 trials
- Aniridia 3 0 trials
- Conjunctival squamous cell carcinoma 0 trials
- Cornea squamous cell carcinoma 0 trials
- Eye carcinoma in situ 0 trials
- Lacrimal gland carcinoma 0 trials Sub-types →
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Pituitary adenocarcinoma 3 trials
3 sub-types
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Carcinoma of floor of mouth 1 trial · 2 incl. sub-types
2 sub-types
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Middle ear carcinoma 1 trial
2 sub-types
- Middle ear adenocarcinoma 0 trials
- Middle ear squamous cell carcinoma 0 trials
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External ear carcinoma 0 trials · 1 incl. sub-types
3 sub-types
- External ear squamous cell carcinoma 1 trial
- Ceruminous carcinoma 0 trials
- External ear basal cell carcinoma 0 trials
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Ameloblastic carcinoma 0 trials
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Laryngeal small cell carcinoma 0 trials
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Pharyngeal adenoid cystic carcinoma 0 trials
Most studied deeper sub-types
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New vaccine aims to train immune system against HPV throat cancer
Disease control CompletedThis study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…
Phase 1/2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Double-Drug attack shows promise for tough head and neck cancers
Disease control CompletedThis study tested whether combining two FDA-approved cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the best dose and see if it improves surv…
Phase 1/2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Cialis and keytruda together against head and neck cancer: small trial shows promise?
Disease control CompletedThis completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…
Phase 2 • Sponsor: University of California, San Diego • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New combo therapy shows promise against tough cancers
Disease control CompletedThis study tested a combination of two drugs—sEphB4-HSA and pembrolizumab—in 42 people with advanced non-small cell lung cancer or head & neck cancer that had spread or returned. The goal was to see if the combo could shrink tumors better than standard treatments. Participants ha…
Phase 2 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Radioactive implants during surgery aim to stop head and neck Cancer's return
Disease control CompletedThis pilot study tested whether placing tiny radioactive seeds (Cesium-131) into the wound during surgery can kill leftover cancer cells in patients whose head and neck cancer has come back. Thirty adults with resectable tumors received the implant right after tumor removal. Rese…
Early phase 1 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Jun 26, 2026 19:05 UTC
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Could a cancer pill before surgery help head and neck patients?
Disease control CompletedThis early-phase trial tested two doses of the drug erlotinib (Tarceva) given before surgery in 48 people with head and neck cancer. The goal was to see how the drug affects a protein called phospho-Akt in tumor samples. Researchers hope erlotinib might slow tumor growth by block…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 26, 2026 13:40 UTC
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Heavy lifting may help cancer survivors rebuild strength
Symptom relief CompletedThis study tests whether a heavy lifting strength training program is safe and helpful for people who have finished treatment for head and neck cancer at least one year ago. Researchers want to see if it improves muscle strength, physical function, fatigue, and quality of life co…
Phase 2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New program aims to ease pain for head and neck cancer survivors
Symptom relief CompletedThis study tested a better pain management program for people who finished treatment for head and neck cancer. 33 survivors with ongoing pain took part. The goal was to see if the program could improve their daily physical function, mood, and overall quality of life.
Sponsor: OHSU Knight Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Walking before surgery may speed recovery for head and neck cancer patients
Symptom relief CompletedThis study tested whether a pre-surgery exercise program (walking, sit-to-stand, and other exercises) could help people recover mobility and avoid complications after head and neck cancer surgery. 52 adults scheduled for major surgery wore Fitbits and either did the exercises or …
Sponsor: OHSU Knight Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Can MRI measurements be trusted for head and neck cancer?
Knowledge-focused CompletedThis study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …
Sponsor: Regina Elena Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Fitness trackers tested in cancer radiation study
Knowledge-focused CompletedThis pilot study looked at whether cancer patients with head and neck, lung, or digestive system cancers could wear a fitness tracker during radiation therapy. The goal was to see if tracking activity levels and quality of life is practical and might relate to treatment outcomes.…
Sponsor: Montefiore Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Snap to clear: photos may help surgeons remove all cancer in one go
Knowledge-focused CompletedThis study tested whether sharing photos between surgeons and pathologists during head and neck cancer surgery could improve the removal of all cancerous tissue. Normally, they only talk by phone. Here, 155 patients had photos taken of their tumors and surgical margins, which wer…
Sponsor: Heidelberg University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can a smartwatch replace doctor visits for cancer patients?
Knowledge-focused CompletedThis study tested whether a wearable device and smartphone app can monitor cancer patients' vital signs and symptoms as well as standard in-clinic checks. About 100 patients with various cancers participated, either after CAR-T cell therapy or during radiation treatment. The goal…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC