H syndrome
MONDO:0011273A systemic inherited histiocytosis, with characteristic cutaneous findings accompanying systemic manifestations. H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and occasionally, hyperglycemia/diabetes mellitus. Due to overlapping clinical features, H syndrome is now considered to include pigmented hypertrichosis with insulin dependent diabetes mellitus syndrome (PHID), Faisalabad histiocytosis (FHC) and familial sinus histiocytosis with massive lymphadenopathy (FSHML).
Also known as: Asrar Facharzt Haque syndrome, H syndrome, Faisalabad histiocytosis, HJCD, Rosai-Dorfman disease, familial, SLC29A3 spectrum disorder, histiocytosis and lymphadenopathy with or without cutaneous, Cardiac, and/or endocrine features, Joint contractures, and/or deafness, histiocytosis with Joint contractures and sensorineural deafness
12 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New drug targets tough childhood cancers with genetic flaws
Disease control CompletedThis phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New serums take on hydroquinone in skin brightening showdown
Symptom relief CompletedThis 4-week pilot study tested two brightening serums against 4% hydroquinone in 18 adults with hyperpigmentation or melasma. Each participant used different products on each side of their face to compare results. The goal was to see if the serums could improve skin tone evenness…
Phase: NA • Sponsor: Revision Skincare • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Oxygen technique during throat surgery may impact heart function
Knowledge-focused CompletedThis study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…
Phase: NA • Sponsor: Region Stockholm • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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New breathing technique may reduce lung injury risk in throat surgery
Knowledge-focused CompletedThis completed study tested two ways of helping patients breathe during microscopic throat surgery. One method uses a steady airflow, while the other uses a set volume of air. The goal was to see which method keeps airway pressure lower and safer. 68 adults having elective laser …
Phase: NA • Sponsor: Kocaeli University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC