H syndrome
MONDO:0011273A systemic inherited histiocytosis, with characteristic cutaneous findings accompanying systemic manifestations. H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and occasionally, hyperglycemia/diabetes mellitus. Due to overlapping clinical features, H syndrome is now considered to include pigmented hypertrichosis with insulin dependent diabetes mellitus syndrome (PHID), Faisalabad histiocytosis (FHC) and familial sinus histiocytosis with massive lymphadenopathy (FSHML).
Also known as: Asrar Facharzt Haque syndrome, H syndrome, Faisalabad histiocytosis, HJCD, Rosai-Dorfman disease, familial, SLC29A3 spectrum disorder, histiocytosis and lymphadenopathy with or without cutaneous, Cardiac, and/or endocrine features, Joint contractures, and/or deafness, histiocytosis with Joint contractures and sensorineural deafness
31 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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HPV vaccine shows promise for girls on Immune-Suppressing drugs
⭐️ VACCINE ⭐️ CompletedThis study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…
Phase: PHASE2 • Sponsor: University Hospital, Bordeaux • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:36 UTC
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New drug targets tough childhood cancers with genetic flaws
Disease control CompletedThis phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New serums take on hydroquinone in skin brightening showdown
Symptom relief CompletedThis 4-week pilot study tested two brightening serums against 4% hydroquinone in 18 adults with hyperpigmentation or melasma. Each participant used different products on each side of their face to compare results. The goal was to see if the serums could improve skin tone evenness…
Phase: NA • Sponsor: Revision Skincare • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Oxygen technique during throat surgery may impact heart function
Knowledge-focused CompletedThis study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…
Phase: NA • Sponsor: Region Stockholm • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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New breathing technique may reduce lung injury risk in throat surgery
Knowledge-focused CompletedThis completed study tested two ways of helping patients breathe during microscopic throat surgery. One method uses a steady airflow, while the other uses a set volume of air. The goal was to see which method keeps airway pressure lower and safer. 68 adults having elective laser …
Phase: NA • Sponsor: Kocaeli University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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AI could cut skin specialist wait times, study hints
Knowledge-focused CompletedThis study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…
Sponsor: AI Labs Group S.L • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Scientists gather clues on mysterious immune defects
Knowledge-focused CompletedThis study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC