Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This trial investigates whether placing a small piece of absorbable material (oxidized regenerated cellulose) over the nerves that control the voice box during total thyroidectomy can improve early voice quality. Thirty adults scheduled for thyroid surgery will be randomly assign…

This study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…

This study tested a new method called the 'Huaxi Tunnel Technique' to protect the recurrent laryngeal nerve during thyroid surgery. The technique uses a diluted epinephrine solution injected along the nerve to create a protective tunnel, reducing the risk of injury. The trial inv…

This study looked at 545 people with hereditary cancer syndromes and their relatives. It compared the usual method of asking patients to share testing information with family members to a new method where a registry also sends reminders. The goal was to see if the registry-aided …

This study tested whether digital care plans and text message reminders help families of children with cancer predisposition syndromes better understand their child's condition. Researchers enrolled 177 parents and measured changes in knowledge and how acceptable the digital tool…

This small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study collected extra blood samples from 28 adults with thyroid disorders to help standardize thyroid-stimulating hormone (TSH) tests. Different labs often use different tests, making it hard to compare results. By analyzing these samples, researchers hope to make …

This completed study followed 183 cancer patients starting checkpoint inhibitor therapy to see how often they develop autoantibodies—proteins that can mistakenly attack the body's own tissues. Researchers collected blood samples to track changes in several types of autoantibodies…

This study looked at whether mailing at-home genetic testing kits to relatives of people with hereditary cancer gene variants could increase the number of relatives who get tested. Researchers compared this approach to usual care in 108 participants. The goal was to see if making…