Fibrodysplasia ossificans progressiva
MONDO:0007606Fibrodysplasia ossificans progressiva (FOP) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification that forms qualitatively normal bone in characteristic extraskeletal sites.
Also known as: FOP, Stone Man syndrome, Stone man syndrome, fibrodysplasia ossificans progressiva, fop, progressive myositis ossificans, myositis ossificans progressiva
9 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Promising drug may halt extra bone formation in rare 'Stone Man' disease
Disease control OngoingThis study tests an experimental drug, garetosmab, in 63 adults with fibrodysplasia ossificans progressiva (FOP), a rare condition where soft tissues turn into bone. The goal is to see if the drug safely reduces new bone growth and painful flare-ups. Participants receive either t…
Phase: PHASE3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Rare bone disease patients get early access to experimental drug
Disease control TEMPORARILY_NOT_AVAILABLEThis program offers garetosmab to adults with fibrodysplasia ossificans progressiva (FOP) who finished the main OPTIMA study. The goal is to provide the drug before it is officially approved. Participants must meet specific health criteria to join.
Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Could this drug stop the body from turning muscle into bone?
Disease control OngoingThis study tests an experimental drug called andecaliximab in 92 children and adults with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition where soft tissues turn into bone. The goal is to see if the drug can safely reduce new bone growth and flare-ups. Parti…
Phase: PHASE2, PHASE3 • Sponsor: Ashibio Inc • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC