Promising drug may halt extra bone formation in rare 'Stone Man' disease
NCT ID NCT05394116
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This study tests an experimental drug, garetosmab, in 63 adults with fibrodysplasia ossificans progressiva (FOP), a rare condition where soft tissues turn into bone. The goal is to see if the drug safely reduces new bone growth and painful flare-ups. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam University Medical Center
Amsterdam, North Holland, 1081 HV, Netherlands
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Clinica Universidad de La Sabana
Chía, Cundinamarca, 140013, Colombia
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HUS Children and Adolescents Park Hospital Clinical Trial Unit
Helsinki, Stenbäckinkatu 11, 00029, Finland
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Hopital Lariboisiere
Paris, 75010, France
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Hospital Israelita Albert Einstein
São Paulo, 05652-900, Brazil
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Hospital Kuala Lampur
Kuala Lumpur, 50586, Malaysia
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hôpital Lapeyronie
Montpellier, 34090, France
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IRCCS Istituto Giannina Gaslini
Genoa, 16147, Italy
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Kyushu University Hospital
Fukuoka, 812-8582, Japan
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Nagoya University Hospital
Nagoya, Aichi-ken, 466-8560, Japan
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Oita University Hospital
Yufu, Oita Prefecture, 879-5593, Japan
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Queen Mary Hospital
Hong Kong, 22553838, Hong Kong
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Royal National Orthropaedic Hospital NHS Trust
Middlesex, Greater London, HA7 4LP, United Kingdom
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Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
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Seoul National University Hospital
Seoul, 03080, South Korea
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Szpital Centrum Medyczne Medyk
Rzeszów, Podkarpackie Voivodeship, 35-326, Poland
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Tongji Hospital of Tongji University
Shanghai, 200065, China
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Universidad de Concepcion
Concepción, Biobio, 4030000, Chile
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University of California Los Angeles (UCLA) Medical Center
Los Angeles, California, 90095, United States
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University of Cape Town
Rondebosch, Cape Town, 7700, South Africa
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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