Familial partial lipodystrophy, Dunnigan type
MONDO:0007906Familial Partial lipodystrophy, Dunnigan type (FPLD2) is a rare form of genetic lipodystrophy characterized by a loss of subcutaneous adipose tissue from the trunk, buttocks and limbs; fat accumulation in the neck, face, axillary and pelvic regions; muscular hypertrophy; and usually associated with metabolic complications such as insulin resistance, diabetes mellitus, dyslipidemia and liver steatosis.
Also known as: Dunnigan syndrome, FPLD2, familial partial lipodystrophy type 2, FPL2, lipodystrophy, familial partial, Dunnigan type, lipodystrophy, familial partial, type 2, lipodystrophy, familial, of limbs and Lower trunk, lipodystrophy, reverse partial
7 clinical trials for this condition and its sub-types.
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Could a simple breakfast replace the glucose drink for diabetes testing?
Diagnosis CompletedThis trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Diagnosis
Last updated Aug 08, 2026 00:03 UTC
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Rare fat disorder gene hunt: just 2 patients could unlock answers
Knowledge-focused CompletedThis study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Researchers investigate Cortisol's role in rare fat disorder
Knowledge-focused CompletedThis study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC