Familial partial lipodystrophy
MONDO:0020088Familial partial lipodystrophy (FPLD) is a group of rare genetic lipodystrophic syndromes characterized, in most cases, by fat loss from the limbs and buttocks, from childhood or early adulthood, and often associated with acanthosis nigricans, insulin resistance, diabetes, hypertriglyceridemia and liver steatosis.
Also known as: FPLD, congenital partial lipodystrophy, genetic partial lipodystrophy, lipodystrophy, familial partial
15 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for rare fat disorder: experimental drug mibavademab under safety review
Disease control CompletedThis study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…
Phase: PHASE3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Could a simple breakfast replace the glucose drink for diabetes testing?
Diagnosis CompletedThis trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Diagnosis
Last updated Aug 08, 2026 00:03 UTC
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Rare fat disorder gene hunt: just 2 patients could unlock answers
Knowledge-focused CompletedThis study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Researchers investigate Cortisol's role in rare fat disorder
Knowledge-focused CompletedThis study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC