Please sign in to follow a disease.
Exfoliative ichthyosis
MONDO:0017339Exfoliative ichthyosis is an inherited, non-syndromic, congenital ichthyosis characterized by the infancy-onset of palmoplantar peeling of the skin (aggravated by exposure to water and by occlusion) associated with dry, scaly skin over most of the body. Pruritus and hypohidrosis may also be associated. Well-demarcated areas of denuded skin appear in moist and traumatized regions and skin biopsies reveal reduced cell-cell adhesion in the basal and suprabasal layers, prominent intercellular edema, numerous aggregates of keratin filaments in basal keratinocytes, attenuated cornified cell envelopes, and epidermal barrier impairment.
Also known as: autosomal recessive exfoliative ichthyosis, exfoliative ichthyosis, ichthyosis exfoliativa
16 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Herbal capsule could offer relief for chronic diarrhea sufferers
Symptom relief Not yet recruitingThis study tests whether Changji'an capsules, a traditional Chinese medicine, can reduce diarrhea and stomach pain in people with irritable bowel syndrome (IBS) where diarrhea is the main symptom. About 636 adults aged 18 to 65 will take the capsule or a placebo for 8 weeks. The …
Phase: PHASE3 • Sponsor: Beijing Hospital of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:39 UTC
-
Could a tiny electrical patch ease IBS-D symptoms?
Symptom relief Not yet recruitingThis study tests whether a small, watch-sized device that delivers mild electrical stimulation to the skin can improve symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). Researchers will compare the real device to a sham (fake) version in 200 adults ag…
Phase: NA • Sponsor: First People's Hospital of Foshan • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
-
Skin deep: european study probes the hidden emotional toll of skin diseases
Knowledge-focused Not yet recruitingThis study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …
Phase: NA • Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
-
New pictograms aim to help children better explain stomach troubles
Knowledge-focused Not yet recruitingThis study will create and test simple picture-based tools (pictograms) to help children aged 8 to 17 describe symptoms like constipation, bloating, and stomach pain. Many kids struggle to explain what they feel, which can lead to misdiagnosis. The goal is to see if these pictogr…
Sponsor: University of Auckland, New Zealand • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC