Disease by molecular mechanism
MONDO:7770011A grouping class for human diseases classified by their underlying molecular or pathophysiological mechanism, such as protein aggregation, ion channel dysfunction, or signal transduction disruption.
1832 clinical trials for this condition and its sub-types, 2 tagged with Disease by molecular mechanism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Disease by molecular mechanism
-
Tauopathy 24 trials · 1,193 incl. sub-types
2 sub-types
- Alzheimer disease 1,187 trials Sub-types →
- Argyrophilic grain disease 0 trials
-
Proteostasis deficiencies 1 trial · 561 incl. sub-types
4 sub-types
- Amyloidosis 133 trials · 323 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- TDP-43 proteinopathy 3 trials
- SQSTM1-related multisystem proteinopathy 0 trials Sub-types →
-
RASopathy 9 trials · 101 incl. sub-types
4 sub-types
- Neurofibromatosis type 1 73 trials Sub-types →
- Noonan syndrome and Noonan-related syndrome 1 trial · 29 incl. sub-types Sub-types →
- Neurofibromatosis-Noonan syndrome 2 trials Sub-types →
- CBL-related disorder 1 trial
-
Ciliopathy 2 trials · 49 incl. sub-types
36 sub-types
- Primary ciliary dyskinesia 34 trials Sub-types →
- Bardet-Biedl syndrome 6 trials · 7 incl. sub-types Sub-types →
- Nephronophthisis 1 4 trials
- CEP290-related ciliopathy 0 trials · 2 incl. sub-types Sub-types →
- Jeune syndrome 1 trial · 2 incl. sub-types Sub-types →
- Joubert syndrome 2 trials Sub-types →
- KIF7-related ciliopathy 0 trials · 2 incl. sub-types Sub-types →
- Senior-Loken syndrome 1 trial · 2 incl. sub-types Sub-types →
- Retinal ciliopathy 0 trials · 2 incl. sub-types Sub-types →
- Alstrom syndrome 1 trial
- BBS1-related ciliopathy 0 trials · 1 incl. sub-types Sub-types →
- MKS1-related ciliopathy 0 trials · 1 incl. sub-types Sub-types →
- Meckel syndrome 0 trials · 1 incl. sub-types Sub-types →
- OFD1-related ciliopathy 0 trials · 1 incl. sub-types Sub-types →
- ARL6-related ciliopathy 0 trials Sub-types →
- Alsahan-Harris syndrome 0 trials
- BBS10-related ciliopathy 0 trials Sub-types →
- BBS12-related ciliopathy 0 trials Sub-types →
- BBS2-related ciliopathy 0 trials Sub-types →
- BBS4-related ciliopathy 0 trials Sub-types →
- BBS5-related ciliopathy 0 trials Sub-types →
- BBS7-related ciliopathy 0 trials Sub-types →
- BBS9-related ciliopathy 0 trials Sub-types →
- CEP164-related ciliopathy 0 trials Sub-types →
- CFAP418-related ciliopathy 0 trials Sub-types →
- IFT140-related recessive ciliopathy 0 trials Sub-types →
- INTU-related skeletal ciliopathy 0 trials Sub-types →
- LZTFL1-related ciliopathy 0 trials Sub-types →
- MKKS-related ciliopathy 0 trials Sub-types →
- Marden-Walker syndrome 0 trials
- SDCCAG8-related ciliopathy 0 trials Sub-types →
- TTC8-related ciliopathy 0 trials Sub-types →
- TUBB4B-related ciliopathy 0 trials Sub-types →
- WDPCP-related ciliopathy 0 trials Sub-types →
- Ciliopathy-IFT74 0 trials Sub-types →
- Oculocerebrodental syndrome 0 trials
-
Muscular channelopathy 0 trials · 19 incl. sub-types
12 sub-types
- Thomsen and Becker disease 9 trials Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- Malignant hyperthermia of anesthesia 5 trials
- SCN4A-related channelopathy 1 trial · 2 incl. sub-types Sub-types →
- Andersen-Tawil syndrome 0 trials
- CNGB3-related retinopathy 0 trials Sub-types →
- Isaac syndrome 0 trials
- Morvan syndrome 0 trials
- Neurological muscular channelopathy due to a genetic calcium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic chloride channel defect 0 trials
- Neurological muscular channelopathy due to a genetic potassium channel defect 0 trials
- Neurological muscular channelopathy due to a genetic sodium channel defect 0 trials
Most studied deeper sub-types
Lewy body dementia
(130)
Multiple system atrophy
(110)
Wild type ATTR amyloidosis
(95)
AL amyloidosis
(93)
Familial amyloid neuropathy
(52)
Wild type ABeta2M amyloidosis
(34)
Early-onset autosomal dominant Alzheimer disease
(31)
Noonan syndrome
(22)
Primary systemic amyloidosis
(22)
Hereditary amyloidosis
(19)
Pure autonomic failure
(18)
Cerebral amyloid angiopathy
(16)
Familial Alzheimer disease
(13)
Multiple system atrophy, parkinsonian type
(12)
Alzheimer disease 2
(11)
ATTRV122I amyloidosis
(7)
Cardiofaciocutaneous syndrome
(7)
Costello syndrome
(7)
Primary ciliary dyskinesia 1
(6)
Alzheimer disease 3
(5)