Please sign in to follow a disease.
Developmental and epileptic encephalopathy
MONDO:0100620An epilepsy associated with developmental impairment that may be due to either the underlying etiology or the superimposed epileptic activity, or both.
Also known as: DEE, developmental and epileptic encephalopathy, infantile spasm
106 clinical trials for this condition and its sub-types, 29 tagged with Developmental and epileptic encephalopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Developmental and epileptic encephalopathy
-
Genetic developmental and epileptic encephalopathy 2 trials · 83 incl. sub-types
105 sub-types
- Dravet syndrome 39 trials
- Lennox-Gastaut syndrome 26 trials · 27 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 2 10 trials
- Developmental and epileptic encephalopathy, 4 6 trials
- Neonatal-onset developmental and epileptic encephalopathy 0 trials · 5 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 11 4 trials
- Developmental and epileptic encephalopathy, 14 3 trials
- Developmental and epileptic encephalopathy, 1 2 trials
- Developmental and epileptic encephalopathy, 17 2 trials
- Developmental and epileptic encephalopathy 114 1 trial
- Developmental and epileptic encephalopathy, 35 1 trial
- Developmental and epileptic encephalopathy, 7 1 trial
- Non-neonatal early infantile epileptic encephalopathy 1 trial
- DNM1-encephalopathy and neurodevelopmental disorder 0 trials Sub-types →
- TMEM63B-related developmental and epileptic encephalopathy with anemia 0 trials
- Developmental and epileptic encephalopathy 100 0 trials
- Developmental and epileptic encephalopathy 101 0 trials
- Developmental and epileptic encephalopathy 102 0 trials
- Developmental and epileptic encephalopathy 103 0 trials
- Developmental and epileptic encephalopathy 104 0 trials
- Developmental and epileptic encephalopathy 105 with hypopituitarism 0 trials
- Developmental and epileptic encephalopathy 106 0 trials
- Developmental and epileptic encephalopathy 107 0 trials
- Developmental and epileptic encephalopathy 108 0 trials
- Developmental and epileptic encephalopathy 109 0 trials
- Developmental and epileptic encephalopathy 110 0 trials
- Developmental and epileptic encephalopathy 111 0 trials
- Developmental and epileptic encephalopathy 112 0 trials
- Developmental and epileptic encephalopathy 113 0 trials
- Developmental and epileptic encephalopathy 115 0 trials
- Developmental and epileptic encephalopathy 116 0 trials
- Developmental and epileptic encephalopathy 118 0 trials
- Developmental and epileptic encephalopathy 119 0 trials
- Developmental and epileptic encephalopathy 120 0 trials
- Developmental and epileptic encephalopathy 121 0 trials
- Developmental and epileptic encephalopathy 6B 0 trials
- Developmental and epileptic encephalopathy 89 0 trials
- Developmental and epileptic encephalopathy 91 0 trials
- Developmental and epileptic encephalopathy 92 0 trials
- Developmental and epileptic encephalopathy 93 0 trials
- Developmental and epileptic encephalopathy 96 0 trials
- Developmental and epileptic encephalopathy 97 0 trials
- Developmental and epileptic encephalopathy 98 0 trials
- Developmental and epileptic encephalopathy 99 0 trials
- Developmental and epileptic encephalopathy, 15 0 trials
- Developmental and epileptic encephalopathy, 18 0 trials
- Developmental and epileptic encephalopathy, 19 0 trials
- Developmental and epileptic encephalopathy, 23 0 trials
- Developmental and epileptic encephalopathy, 27 0 trials
- Developmental and epileptic encephalopathy, 3 0 trials
- Developmental and epileptic encephalopathy, 30 0 trials
- Developmental and epileptic encephalopathy, 36 0 trials
- Developmental and epileptic encephalopathy, 37 0 trials
- Developmental and epileptic encephalopathy, 38 0 trials
- Developmental and epileptic encephalopathy, 40 0 trials
- Developmental and epileptic encephalopathy, 48 0 trials
- Developmental and epileptic encephalopathy, 49 0 trials
- Developmental and epileptic encephalopathy, 5 0 trials
- Developmental and epileptic encephalopathy, 50 0 trials
- Developmental and epileptic encephalopathy, 51 0 trials
- Developmental and epileptic encephalopathy, 52 0 trials
- Developmental and epileptic encephalopathy, 53 0 trials
- Developmental and epileptic encephalopathy, 54 0 trials
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 56 0 trials
- Developmental and epileptic encephalopathy, 57 0 trials
- Developmental and epileptic encephalopathy, 58 0 trials
- Developmental and epileptic encephalopathy, 59 0 trials
- Developmental and epileptic encephalopathy, 60 0 trials
- Developmental and epileptic encephalopathy, 61 0 trials
- Developmental and epileptic encephalopathy, 62 0 trials
- Developmental and epileptic encephalopathy, 63 0 trials
- Developmental and epileptic encephalopathy, 64 0 trials
- Developmental and epileptic encephalopathy, 65 0 trials
- Developmental and epileptic encephalopathy, 66 0 trials
- Developmental and epileptic encephalopathy, 67 0 trials
- Developmental and epileptic encephalopathy, 68 0 trials
- Developmental and epileptic encephalopathy, 69 0 trials
- Developmental and epileptic encephalopathy, 6A 0 trials
- Developmental and epileptic encephalopathy, 70 0 trials
- Developmental and epileptic encephalopathy, 71 0 trials
- Developmental and epileptic encephalopathy, 72 0 trials
- Developmental and epileptic encephalopathy, 73 0 trials
- Developmental and epileptic encephalopathy, 74 0 trials
- Developmental and epileptic encephalopathy, 75 0 trials
- Developmental and epileptic encephalopathy, 76 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 78 0 trials
- Developmental and epileptic encephalopathy, 79 0 trials
- Developmental and epileptic encephalopathy, 8 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Developmental and epileptic encephalopathy, 81 0 trials
- Developmental and epileptic encephalopathy, 82 0 trials
- Developmental and epileptic encephalopathy, 83 0 trials
- Developmental and epileptic encephalopathy, 84 0 trials
- Developmental and epileptic encephalopathy, 85, with or without midline brain defects 0 trials
- Developmental and epileptic encephalopathy, 86 0 trials
- Developmental and epileptic encephalopathy, 87 0 trials
- Developmental and epileptic encephalopathy, 88 0 trials
- Developmental and epileptic encephalopathy, 9 0 trials
- Developmental and epileptic encephalopathy, 90 0 trials
- Hemiplegic migraine-developmental and epileptic encephalopathy spectrum 0 trials
- Microcephaly, seizures, and developmental delay 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Neonatal-onset encephalopathy with rigidity and seizures 0 trials
-
Early-infantile DEE 2 trials
3 sub-types
Most studied deeper sub-types
-
New hope for Hard-to-Treat seizures: phase 3 trial launches
Disease control OngoingThis study tests an experimental drug called LP352 to see if it can safely reduce seizures in children and adults with developmental and epileptic encephalopathies (DEE), a group of severe epilepsy syndromes. About 320 participants will receive either LP352 or a placebo, and rese…
Phase 3 • Sponsor: Longboard Pharmaceuticals • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
-
New drug LP352 aims to control seizures in severe epilepsy over the long term
Disease control By invitation onlyThis phase 3 study is testing the long-term safety and effectiveness of LP352 (Bexicaserin) in 324 children and adults with developmental and epileptic encephalopathy (DEE), including Dravet and Lennox-Gastaut syndromes. Participants who completed earlier studies will receive LP3…
Phase 3 • Sponsor: Longboard Pharmaceuticals • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
-
New hope for kids with rare epilepsy: drug trial targets seizure control
Disease control OngoingThis study tests an investigational drug called relutrigine in 160 children with a severe form of epilepsy called developmental and epileptic encephalopathy (DEE). The goal is to see if the drug can safely reduce monthly seizure frequency compared to a placebo. After the initial …
Phase 3 • Sponsor: Praxis Precision Medicines • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
-
Could a urea cycle drug help kids with rare epilepsy?
Disease control OngoingThis early-phase trial is testing whether glycerol phenylbutyrate (Ravicti), a drug already approved for a different condition, is safe and tolerable for children with genetic disorders like STXBP1 and SLC6A1 that cause seizures and developmental delays. The study will enroll 50 …
Early phase 1 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC