Desmoid tumor
MONDO:0007608A desmoid tumor (DT) is a benign, locally invasive soft tissue tumor associated with a high recurrence rate but with no metastatic potential.
Also known as: aggressive fibromatosis, deep fibromatosis, deep fibromatosis/desmoid tumor, deep fibromatosis/desmoid tumour, desmoid fibromatosis, desmoid tumor, desmoid type fibromatosis, desmoid-type fibromatosis
1477 clinical trials for this condition and its sub-types, 36 tagged with Desmoid tumor itself.
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Sub-types of Desmoid tumor
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Old drugs, new hope: imatinib combo tested for rare tumors
Disease control CompletedThis early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…
Phase 1 • Sponsor: Centre Oscar Lambret • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Can a pill stop desmoid tumors from growing?
Disease control CompletedThis phase 3 trial investigates whether nirogacestat, an oral drug, can slow the growth of desmoid tumors (also called aggressive fibromatosis) in adults whose tumors are progressing. Half the participants receive nirogacestat, while the other half receive a placebo, in a double-…
Phase 3 • Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Cancer drug shows promise in slowing rare tumor growth
Disease control CompletedThis Phase 3 trial tested the drug sorafenib in 87 people with desmoid tumors, a rare type of growth that can be painful and invasive. The study compared sorafenib to a placebo to see if it could slow tumor progression. Sorafenib works by blocking proteins that help tumors grow. …
Phase 3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Freezing out tumors: new hope for rare desmoid disease
Disease control CompletedThis study tested a freezing technique called cryoablation on 50 adults with desmoid tumors that had grown despite medical treatment. The goal was to stop tumor growth and ease symptoms without surgery. Researchers used MRI to guide the freezing and check results one year later.
Sponsor: University Hospital, Strasbourg, France • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New Tamoxifen-Like drug tested for stubborn hormone cancers
Disease control CompletedThis early-stage trial tested an experimental drug called Z-Endoxifen in 40 adults with hormone receptor-positive cancers (like breast, ovarian, or desmoid tumors) that had stopped responding to standard treatments. Z-Endoxifen is a direct form of tamoxifen's active ingredient, b…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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New pill could tame rare, aggressive tumors without surgery
Disease control CompletedThis phase 2 trial tested the drug pazopanib against a standard chemotherapy combination (vinblastine and methotrexate) in 72 adults with progressive desmoid tumors. Desmoid tumors are non-cancerous but can grow aggressively and come back after surgery. The study measured how man…
Phase 2 • Sponsor: Institut Bergonié • Aim: Disease control
Last updated Jun 26, 2026 14:17 UTC
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Can a Stress-Management program help young cancer patients cope?
Symptom relief CompletedThis study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…
Sponsor: Dana-Farber Cancer Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Desmoid tumor study: is doing nothing the best medicine?
Knowledge-focused CompletedThis study looked at 100 people with desmoid tumors (a rare, non-cancerous growth) to see what happens when doctors don't treat them right away. Instead, patients were monitored closely with scans, and treatment only started if the tumor grew. The goal was to learn how often thes…
Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:31 UTC