Cryptococcal meningitis
MONDO:0005723Meningeal inflammation produced by cryptococcus neoformans, an encapsulated yeast that tends to infect individuals with acquired immunodeficiency syndrome and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature headache; nausea; photophobia; focal neurologic deficits; seizures; cranial neuropathies; and hydrocephalus. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
Also known as: Cryptococcus neoformans caused infectious meningitis, Cryptococcus neoformans infectious meningitis
15 clinical trials for this condition and its sub-types.
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Could a shorter drug course beat a longer one for a deadly fungal infection?
Disease control Not yet recruitingThis trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…
Phase: PHASE3 • Sponsor: University of Minnesota • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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Can a cancer drug wake up immune cells to beat HIV-Related infections?
Disease control Not yet recruitingThis study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…
Phase: PHASE1, PHASE2 • Sponsor: Shanghai Public Health Clinical Center • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Rapid brain infection test could slash unnecessary antibiotic use
Diagnosis Not yet recruitingThis study looks at whether a quick diagnostic test (BioFire FilmArray) can accurately predict the cause of meningitis or encephalitis in 182 adults. Participants with symptoms like fever, headache, or confusion will have their spinal fluid tested. The goal is to see if the test …
Phase: NA • Sponsor: Federal University of Health Science of Porto Alegre • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Could a common steroid prevent a deadly complication in AIDS patients?
Prevention Not yet recruitingThis study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…
Phase: NA • Sponsor: Shanghai Public Health Clinical Center • Aim: Prevention
Last updated Jun 27, 2026 12:29 UTC
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Can we predict who survives meningitis? a new study seeks answers
Knowledge-focused Not yet recruitingThis study looks at the medical records of 300 people treated for meningitis at a hospital in Sohag, Egypt, to understand what factors influence their chances of recovery. Researchers will review past cases and follow new patients for a year, tracking who survives, who recovers f…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Aug 18, 2026 07:00 UTC