Creutzfeldt Jacob disease
MONDO:0005357A rare transmittable degenerative disorder of the brain caused by prions. Morphologically it is characterized by spongiform degeneration of the cerebral and cerebellar cortex. Signs and symptoms include sleep disturbances, personality changes, aphasia, ataxia, muscle atrophy and weakness, visual loss, and myoclonus. It usually leads to death within a year from the onset of the disease.
Also known as: CJD, CJD (Creutzfeldt Jakob disease), Creutzfeldt Jakob Disease, Creutzfeldt-Jacob disease, Jakob-Creutzfeldt disease, classic Creutzfeldt-Jakob disease, Creutzfeldt-Jakob disease
7 clinical trials for this condition and its sub-types, 4 tagged with Creutzfeldt Jacob disease itself.
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Sub-types of Creutzfeldt Jacob disease
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Inherited Creutzfeldt-Jakob disease 5 trials
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Acquired Creutzfeldt-Jakob disease 0 trials
2 sub-types
- Iatrogenic Creutzfeldt-Jakob disease 0 trials
- Variant Creutzfeldt-Jakob disease 0 trials
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Sporadic Creutzfeldt-Jakob disease 0 trials
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Could an HIV drug extend life in Creutzfeldt-Jakob disease?
Disease control Recruiting nowThis study tests whether efavirenz, a drug used for HIV, can help people with Creutzfeldt-Jakob disease (CJD) live longer. CJD is a rare, rapidly fatal brain disorder. The trial will enroll 246 adults and randomly assign them to receive either efavirenz or a placebo. The main goa…
Phase 3 • Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Could a single injection silence fatal brain disease?
Disease control Recruiting nowThis study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …
Phase 1 • Sponsor: Broad Institute of MIT and Harvard • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC