Craniopharyngioma
MONDO:0018907A benign, partly cystic, epithelial tumor of the sellar region, presumably derived from Rathke pouch epithelium. It affects mainly children and young adults. There are two clinicopathological forms: adamantinomatous craniopharyngioma and papillary craniopharyngioma. The most significant factor associated with recurrence is the extent of surgical resection, with lesions greater than 5 cm in diameter carrying a markedly worse prognosis. (Adapted from WHO)
Also known as: Rathke pouch neoplasm, Rathke pouch tumor, Rathke pouch tumour, Rathke's pouch neoplasm, Rathke's pouch tumor, Rathke's pouch tumour, craniopharyngioma (WHO grade I), craniopharyngioma (morphologic abnormality)
1497 clinical trials for this condition and its sub-types, 29 tagged with Craniopharyngioma itself.
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Sub-types of Craniopharyngioma
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Adamantinous craniopharyngioma 5 trials
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Papillary craniopharyngioma 1 trial
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Could a dementia drug shield kids' brains from radiation damage?
Disease control CompletedThis pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Can a diabetes drug tame obesity caused by brain tumor treatment?
Disease control CompletedThis study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…
Phase 3 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Glowing dye could help surgeons spot hidden brain tumor cells
Diagnosis CompletedThis study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of b…
Phase 2 • Sponsor: John Yu • Aim: Diagnosis
Last updated Jul 12, 2026 00:00 UTC
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Brain scan grading predicts growth problems in child tumor survivors
Knowledge-focused CompletedThis study looked at 500 children who had surgery for a rare brain tumor called craniopharyngioma. Researchers used MRI scans to grade how much the tumor damaged a key brain area (the hypothalamus). They found that more damage was linked to higher rates of growth hormone deficien…
Sponsor: West China Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Can a Child's tumor DNA guide better cancer treatment?
Knowledge-focused CompletedThis study tested whether analyzing the DNA and RNA of a child's tumor could help doctors choose personalized treatments. It included 186 children with relapsed or hard-to-treat cancers like neuroblastoma and brain tumors. The goal was to see if this approach was feasible and saf…
Sponsor: Giselle Sholler • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC