Cowden disease
MONDO:0016063A genodermatosis characterized by the presence of multiple hamartomas in various tissues and an increased risk for malignancies of the breast, thyroid, endometrium, kidney and colorectum. When CS is accompanied by germline PTEN mutations, it belongs to the PTEN hamartoma tumor syndrome (PHTS) group.
Also known as: Cowden disease, Cowden syndrome, Cowden's disease, multiple hamartoma syndrome, CD, MHAM, dysplastic gangliocytoma of cerebellum
17 clinical trials for this condition and its sub-types.
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Broader categories
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Could a cancer drug boost social abilities in rare genetic condition?
Disease control Not yet recruitingThis study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …
Phase: PHASE2, PHASE3 • Sponsor: Boston Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Skin deep: european study probes the hidden emotional toll of skin diseases
Knowledge-focused Not yet recruitingThis study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …
Phase: NA • Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC