Congenital anomalies of kidney and urinary tract 2
MONDO:0027676Any congenital anomaly of kidney and urinary tract in which the cause of the disease is a mutation in the TBX18 gene.
Also known as: TBX18 congenital anomaly of kidney and urinary tract, congenital anomalies of kidney and urinary tract 2, congenital anomalies of kidney and urinary tract type 2, congenital anomaly of kidney and urinary tract caused by mutation in TBX18, CAKUT2, hydronephrosis due to Pujo, multicystic renal dysplasia, bilateral, pelviureteric junction obstruction
23 clinical trials for this condition and its sub-types.
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Experimental fetal fluid therapy aims to save babies born without kidneys
Disease control CompletedThis trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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MRI may spare babies radiation in kidney blockage diagnosis
Diagnosis CompletedThis study looked at whether functional MRI can accurately measure kidney function in children with pyelo-ureteral junction syndrome, a common urinary blockage. Researchers compared MRI results to the standard scintigraphy scan in 270 children aged 0-17. The goal was to see if MR…
Sponsor: Central Hospital, Nancy, France • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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Sweat sensor could replace needles for kidney patients
Diagnosis CompletedThis study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…
Phase: NA • Sponsor: Korea University • Aim: Diagnosis
Last updated Jun 27, 2026 08:11 UTC
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New laser microscope could spot urinary tract tumors without needles
Diagnosis CompletedThis study tested whether a laser confocal microscope, used during a kidney-ureter scope procedure, can tell the difference between normal and cancerous tissue in the upper urinary tract. 29 adults with conditions like blood in urine, kidney stones, or urinary tract cancer took p…
Phase: NA • Sponsor: Lille Catholic University • Aim: Diagnosis
Last updated Jun 27, 2026 08:06 UTC
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Ketamine boosts pain relief for infants after kidney surgery
Symptom relief CompletedThis study looked at 40 infants under 1 year old having kidney surgery. They received a pain block with either bupivacaine alone or bupivacaine plus ketamine. The goal was to see if adding ketamine reduces pain and the need for extra pain medicine after surgery.
Phase: PHASE4 • Sponsor: Alexandria University • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Barbed sutures may speed up kidney surgery, small trial suggests
Symptom relief CompletedThis study tested whether barbed sutures (V-Loc) are safer and easier to use than standard polyglactin sutures (Vicryl) in minimally invasive kidney surgery for a blocked ureter. Forty adults aged 18 to 60 were randomly assigned to receive either barbed or standard sutures during…
Phase: PHASE3 • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Gene sequencing uncovers mysterious fetal malformations
Knowledge-focused CompletedThis study tested whether a powerful DNA test called high-throughput exome sequencing can find genetic causes of multiple birth defects in fetuses when standard exams fail. Researchers studied 100 fetuses with at least two malformations and no prior diagnosis. They compared the n…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Speedy gene test aims to give answers on birth defects in just 7 days
Knowledge-focused CompletedThis study tested whether a fast type of genetic test called rapid genome sequencing can find the cause of birth defects seen on ultrasound more quickly than current methods. Researchers included 184 pregnancies with certain ultrasound findings. The goal was to see if results cou…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC