Central nervous system malformation

This study tests whether a fluorescent dye called 5-ALA can help surgeons see and remove abnormal brain tissue in people with drug-resistant epilepsy caused by focal cortical dysplasia (FCD). FCD lesions are often hard to distinguish from healthy brain during surgery, making comp…

This study tests whether everolimus, a drug already approved for other conditions, can safely improve social abilities in people with PTEN Hamartoma Tumor Syndrome (PHTS). About 60 adults and children with PHTS and social difficulties will take either everolimus or a placebo for …

This early-stage trial tests an oral drug called SVG103 (Paxalisib) in 15 adults with rare brain conditions (FCD-II, TSC, or HME) that cause seizures. The main goal is to check safety and side effects, while also seeing if it reduces seizure frequency. Participants take the drug …

This study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …

This study looks at whether electrical pudendal nerve stimulation (EPNS), delivered through thin needles near the tailbone, can improve bladder function in children who have nerve-related bladder issues after tethered cord surgery. Fifty children will receive EPNS three times a w…

This study looks at children with spinal dysraphism, a birth defect where the spine doesn't close properly. The goal is to better understand bladder and bowel problems in these children, especially those with less obvious forms. By studying 210 children treated at one hospital ov…