Central diabetes insipidus
MONDO:0015790Central diabetes insipidus (CDI) is a hypothalamus-pituitary disease characterized by polyuria and polydipsia due to a vasopressin (AVP) deficiency. It can be inherited or acquired (hereditary CDI and acquired CDI).
Also known as: CDI, neurogenic diabetes insipidus, diabetes insipidus cranial type, diabetes insipidus neurogenic, diabetes insipidus neurohypophyseal
12 clinical trials for this condition and its sub-types.
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Broader categories
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Sugar alcohol infusion may help diagnose thirst disorders
Diagnosis CompletedThis study tested whether infusing mannitol, a sugar alcohol, can help diagnose polyuria-polydipsia syndrome—a condition of excessive thirst and urination. Researchers measured copeptin levels in 42 healthy adults and patients after mannitol or placebo infusion. The goal was to s…
Phase: NA • Sponsor: University Hospital, Basel, Switzerland • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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Can estrogen boost the 'Love Hormone' in a rare condition?
Knowledge-focused CompletedThis pilot study tested whether a single dose of oral estrogen-progestin can raise oxytocin levels in people with arginine vasopressin deficiency (AVD), a rare condition that also causes low oxytocin. Researchers compared 28 adults—some with AVD and some healthy—to see if oxytoci…
Phase: EARLY_PHASE1 • Sponsor: Elizabeth Austen Lawson • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Can a diabetes drug reveal hidden hormone deficiencies?
Knowledge-focused CompletedThis study tested whether people with hypopituitarism (a condition where the pituitary gland doesn't work properly) have lower oxytocin levels compared to healthy individuals. Researchers gave participants a drug called exenatide (a GLP1 receptor agonist) to see if it could stimu…
Phase: PHASE4 • Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC