Carcinoma of the ampulla of vater
MONDO:0017590A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss.
Also known as: Ampulloma, ampulla of Vater cancer, ampulla of Vater carcinoma, ampullary cancer, ampullary carcinoma, carcinoma of ampulla of vater, carcinoma of hepatopancreatic ampulla, hepatopancreatic ampulla carcinoma
3025 clinical trials for this condition and its sub-types, 29 tagged with Carcinoma of the ampulla of vater itself.
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Sub-types of Carcinoma of the ampulla of vater
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Ampulla of vater adenocarcinoma 11 trials · 42 incl. sub-types
4 sub-types
- Periampullary adenocarcinoma 33 trials
- Ampulla of vater clear cell adenocarcinoma 0 trials
- Ampulla of vater mucinous adenocarcinoma 0 trials
- Ampullary signet ring cell adenocarcinoma 0 trials
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1 sub-type
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New combo therapy shows promise for Tough-to-Treat bile duct cancer
Disease control OngoingThis study tests whether adding the experimental drug CTX-009 to standard chemotherapy (paclitaxel) helps adults with advanced bile duct, gallbladder, or ampullary cancer that has worsened after one prior treatment. About 168 participants will be randomly assigned to receive eith…
Phase 2/3 • Sponsor: Compass Therapeutics • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Supercharged immune cells take on hard-to-treat pancreatic cancer
Disease control PausedThis early-phase study tests a new combination treatment for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, given through a belly infusion and a vein,…
Phase 1/2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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New combo therapy shows promise for bile duct cancer
Disease control OngoingThis phase 3 trial is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy can help people with advanced biliary tract cancer (a type of bile duct cancer). About 142 participants will receive the combination, and researchers will track side effects, s…
Phase 3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Immune cells take on rare bile duct cancer in early trial
Disease control OngoingThis early-phase trial tests whether a patient's own immune cells, called tumor-infiltrating lymphocytes (TIL), can shrink advanced bile duct cancers. Four participants receive chemotherapy to prepare their immune system, then an infusion of their own TIL cells plus high-dose ald…
Phase 2 • Sponsor: Udai Kammula • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Shorter antibiotics after pancreatic surgery may cut hospital stays
Disease control PausedThis study compares two approaches to prevent pancreatic leaks after Whipple surgery: giving antibiotics for a short time with a drug called octreotide versus giving antibiotics for a longer time. About 103 adults at intermediate or high risk for leaks will take part. The goal is…
Phase 2/3 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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New biomarkers may sharpen cancer diagnosis in bile duct blockages
Diagnosis OngoingThis study looks at whether measuring certain substances in bile and blood can more accurately diagnose cancer in people with bile duct blockages. Researchers will compare these new tests with standard methods in 500 adults undergoing a procedure called ERCP. The goal is to find …
Sponsor: AdventHealth • Aim: Diagnosis
Last updated Jun 27, 2026 09:02 UTC