Brain glioma

This study tests a drug called olaparib in people with advanced cancers (like brain tumors, bile duct cancer, or other solid tumors) that have a specific gene change called IDH1 or IDH2 mutation. The drug works by blocking an enzyme that cancer cells need to grow. About 89 partic…

This early-stage study tests whether adding a drug called acetazolamide to standard chemotherapy (temozolomide) is safe for people with a newly diagnosed, aggressive brain cancer (glioblastoma). Ten adults will take both drugs daily for 21-day cycles. The main goal is to find any…

This phase 2 trial tests the drug trametinib in children and young adults (ages 1 month to 25 years) with low-grade glioma or plexiform neurofibroma that has not responded to prior treatment. Participants take a daily oral dose for up to 18 cycles. The study aims to see if the dr…

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This study aimed to test an experimental virus therapy called G207, combined with a single dose of radiation, in children whose high-grade glioma had come back after prior treatment. The virus was injected directly into the brain tumor to kill cancer cells and trigger an immune r…

This study is testing two different imaging techniques—SPECT and PET—to see how well they can spot brain tumors called gliomas. Forty patients with primary or recurrent glioma will receive injections of two special tracers, then undergo scans to measure how much tracer is taken u…

This program gave patients with glioma (a type of brain tumor) access to a special imaging agent called 18F-FET. It was used with PET scans to help doctors tell the difference between actual tumor growth and changes caused by previous treatments. The goal was to improve treatment…

This phase 2 pilot study is testing whether mirtazapine, an antidepressant, can help with depression, nausea, vomiting, and weight loss in people with high-grade glioma who are starting temozolomide chemotherapy. The study enrolled 120 adults with newly diagnosed glioma. Research…

This pilot study aimed to see if a diet low in two specific nutrients (cysteine and methionine) could affect metabolism in patients with recurrent gliomas. Up to 30 participants were to be randomly assigned to either a normal diet or the special diet for 2, 4, or 7 days before st…