Biliary atresia

This Phase 3 study tests odevixibat, a daily pill, in 254 children with biliary atresia who recently had Kasai surgery. The goal is to see if the drug can prevent the need for a liver transplant or death. Children take either odevixibat or a placebo for up to 2 years, and researc…

This study looked at the long-term safety of a drug called maralixibat in 52 people with cholestatic liver disease, including Alagille Syndrome and other rare conditions. Participants had already taken maralixibat in an earlier study. Researchers tracked side effects and how well…

This completed study tested a device called NvisionVLE® that helps doctors see bile duct details during a procedure called ERCP. Only 3 adults who had the procedure between 2017 and 2019 took part. The goal was to check if the device is safe and can better find abnormalities to g…

This study tested whether a wired magnetic capsule endoscopy system produces fewer airborne droplets than traditional endoscopy when checking for esophageal varices in people with biliary atresia. Fifty participants underwent either the capsule or standard procedure. The main goa…

This study reviewed medical records of 320 children with biliary atresia, a rare liver disease, treated at hospitals in the northeastern U.S. between 2012 and 2021. The goal was to find which factors lead to better outcomes, such as avoiding liver transplant or clearing jaundice.…

This study followed 200 babies with biliary atresia who had Kasai surgery at different ages to see which timing gives the best chance of keeping their own liver healthy for two years. Researchers grouped babies by surgery age (from under 28 days to 120 days) and tracked how many …