Autosomal dominant polycystic kidney disease

This Phase 3 trial tested whether lanreotide, a drug that blocks certain growth hormones, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Participants received ei…

This study followed 1802 Japanese patients with autosomal dominant polycystic kidney disease (ADPKD) who were taking tolvaptan in real-world clinics. Researchers tracked safety and how well the drug slowed kidney growth. The goal was to see if tolvaptan works as well outside cont…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…

This study followed over 3,400 people with autosomal dominant polycystic kidney disease (ADPKD) to learn how the disease progresses. Researchers measured kidney size, symptoms, quality of life, and healthcare costs. The goal was to identify factors that predict faster disease pro…

This study looked at how a new drug called VX-407 changes the way birth control pills work in the body. 74 healthy adults took VX-407 along with different types of oral contraceptives. The goal was to see if VX-407 affects the levels of these contraceptives, which is important fo…

This early-stage study tested the safety and how the body handles a new drug called VX-407 in 32 healthy adults. The goal was to check for side effects and measure drug levels in the blood. No treatment benefit was expected, as this study was designed to gather safety information…

This study examined 10 people with autosomal dominant polycystic kidney disease (ADPKD) to see if a specific deletion in the PKD2 gene is shared among families in the Bergamo area. Researchers interviewed participants and built family trees to understand how the gene change affec…

This study followed 530 adults with autosomal dominant polycystic kidney disease (ADPKD) who were already taking the drug tolvaptan (JINARC™). Researchers wanted to see how the medication affected their quality of life, pain, and daily activities, as well as how long it took befo…

This study looked at 44 couples where one or both partners have polycystic kidney disease (PKD). They used IVF combined with genetic testing to select embryos without the disease. The goal was to see how often these treatments led to a healthy pregnancy and live birth, and to tra…