Autosomal dominant optic atrophy
MONDO:0020250An autosomal dominant hereditary condition characterized by optic atrophy and progressive visual loss.
Also known as: ADOA, DOA, optic atrophy, autosomal dominant, dominant optic atrophy
9 clinical trials for this condition and its sub-types, 6 tagged with Autosomal dominant optic atrophy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Autosomal dominant optic atrophy
-
4 sub-types
- Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome 0 trials
- Optic atrophy 8 0 trials
- Optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 0 trials
- Optic atrophy, hearing loss, and peripheral neuropathy, autosomal dominant 0 trials
-
Optic atrophy 3 0 trials
-
Optic atrophy 5 0 trials
-
Could stem cells restore sight in damaged eyes?
Disease control Recruiting nowThis study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…
Sponsor: MD Stem Cells • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
-
New eye drug hopes to slow inherited blindness
Disease control Recruiting nowThis early-stage study tests a new medicine called PYC-001, given as an injection into the eye, for people with a rare genetic eye disease (autosomal dominant optic atrophy) caused by a change in the OPA1 gene. The main goal is to check the safety of different doses and schedules…
Phase 1/2 • Sponsor: PYC Therapeutics • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
-
New laser device could revolutionize eye disease detection
Knowledge-focused Recruiting nowThis study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…
Sponsor: Randy Kardon • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
-
Can eye tests track an inherited form of blindness?
Knowledge-focused Recruiting nowThis study follows people with a genetic condition called OPA1-associated optic atrophy, which causes gradual vision loss. Researchers will use a battery of eye exams—including vision charts, contrast sensitivity, and retinal imaging—to see how the disease changes over time. The …
Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Jul 30, 2026 00:00 UTC