Aortic valve insufficiency
MONDO:0005648Dysfunction of the aortic valve characterized by incomplete valve closure.
Also known as: aortic insufficiency, rheumatic aortic insufficiency, rheumatic aortic regurgitation
110 clinical trials for this condition and its sub-types, 56 tagged with Aortic valve insufficiency itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Aortic valve insufficiency
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Can a new valve fix a leaky heart without open surgery?
Disease control Not yet recruitingThis trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…
Sponsor: Ceric Sàrl • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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No X-Rays, no dye: new heart valve procedure could protect kidneys
Disease control Not yet recruitingThis study tests a new way to replace a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye, which can harm the kidneys. Instead, doctors will use only ultrasound (echocardiography) to guide the procedure. The goal is to see if this approach is safe and …
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New valve procedure aims to fix leaky heart in pump patients
Disease control Not yet recruitingThis study tests a new device called the J-Valve Transfemoral System in 50 adults who have a heart pump (LVAD) and a severely leaking aortic valve. The valve is replaced through a blood vessel, avoiding open-heart surgery. The goal is to see if it safely stops the leak and improv…
Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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No X-Ray, no dye: new heart valve procedure could spare patients harmful exposure
Disease control Not yet recruitingThis study tests a new way to replace the aortic valve in people with a leaky heart valve (aortic regurgitation) without using X-rays or contrast dye. Instead, doctors will rely on ultrasound (TEE) to guide the procedure. The goal is to see if this approach is safe and effective,…
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Smaller incision, faster recovery? new study tests heart valve surgery approaches
Symptom relief Not yet recruitingThis study compares two types of heart valve surgery: a newer, less invasive method through a small cut on the right side of the chest versus the traditional method through a cut down the middle of the chest. Researchers will measure how quickly patients recover, including time o…
Sponsor: Chaudhry Pervaiz Elahi Institute of Cardiology • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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5,500 patients to test new heart valve devices in massive safety study
Knowledge-focused Not yet recruitingThis study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…
Sponsor: Beijing Anzhen Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Heart surgery monitoring under the microscope: is the standard test accurate enough?
Knowledge-focused Not yet recruitingThis study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:15 UTC