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Anti-HLA hyperimmunization

MONDO:0016351

Anti-HLA hyperimmunization is an increase in anti-HLA antigens mostly seen in chronic renal failure (CRF) patients that have undergone hemodialysis and polytransfusion.

3 clinical trials for this condition and its sub-types.

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Broader categories

Disease (717) Immune system disorder (150) Human disease (15) Disease by body system or component (0)

Trials to join now! 1 Not yet recruiting 1 Terminated 1

BiTE antibodies could unlock transplants for 'Incompatible' kidney patients

Disease control Not yet recruiting

This trial tests two BiTE drugs (blinatumomab and teclistamab) in 20 adults with end-stage kidney disease who have very high antibody levels (cPRA ≥90%) and have waited over 5 years for a transplant. The goal is to safely lower these antibodies enough to make a kidney transplant …

Phase 4 • Sponsor: West China Hospital • Aim: Disease control

Last updated Jul 10, 2026 00:00 UTC