Anemia due to chronic disorder

This study tests a gradual switch from the injected drug Epogen to an oral medication called vadadustat for people with anemia who are on dialysis. The goal is to see if patients can stay on vadadustat long-term without stomach issues or drops in red blood cell levels. About 100 …

This study tests whether adding a pill called vadadustat to standard anemia treatment helps people on dialysis feel better and have higher hemoglobin levels. Forty adults on peritoneal dialysis will receive either vadadustat plus their usual shot or just the shot alone for 8 week…

This early-stage study tests a new treatment using special immune cells (CAR-T cells) designed to reduce harmful antibodies that can prevent or damage bone marrow transplants. About 18 people with blood diseases who have these antibodies will receive the cells in increasing doses…

This study will test whether SGLT2 inhibitors, a type of diabetes drug, can help correct anemia in people with chronic kidney disease (CKD). Anemia is common in CKD and often requires iron or hormone injections, which have side effects. The trial will enroll 60 adults with CKD st…

This study tests whether starting tube feeding right after a stem cell transplant can reduce severe gut graft-versus-host disease (GVHD) in people with blood cancers or disorders. About 112 participants will be randomly assigned to either standard care or early tube feeding. The …

This study tests a new pill called daprodustat against a standard injectable drug (darbepoetin alfa) for treating anemia in people on hemodialysis. About 100 Chinese adults will take either the pill daily or the injection weekly for 28 weeks. The goal is to see if the pill works …

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This study tests whether roxadustat, a drug currently used to treat anemia in kidney disease, can also improve sarcopenia (muscle loss) in patients on hemodialysis. Sixty adults with end-stage kidney disease and anemia will receive either roxadustat or standard erythropoietin. Re…

This Phase 2 trial tests an oral drug called AND017 for anemia (low red blood cells) in cancer patients who are not receiving chemotherapy. The study will enroll 36 participants to see if different doses of AND017 can safely raise hemoglobin levels over 6 weeks. The goal is to re…

This Phase 2 trial tests an oral drug called AND017 for cancer-related anemia caused by chemotherapy. About 36 adults with non-myeloid cancers and low hemoglobin will take AND017 three times a week for 6 weeks. The goal is to see if it safely raises hemoglobin levels and reduces …

This study looks at how different types of anemia—like iron deficiency or thalassemia—can change HbA1c levels, a common test for diabetes, in people who do not have diabetes. Researchers will compare HbA1c results between 100 non-diabetic adults with various anemias and a healthy…

This study is a registry that will collect information from 384 adults with chronic kidney disease (CKD) and anemia who are taking or starting the drug daprodustat. The goal is to understand how the drug works in everyday medical practice, including its effects on hemoglobin leve…