Anemia
MONDO:0002280A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
Also known as: anaemia (disease), anemia, anemia (disease)
975 clinical trials for this condition and its sub-types, 258 tagged with Anemia itself.
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Sub-types of Anemia
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Aplastic anemia 110 trials · 411 incl. sub-types
4 sub-types
- Acquired aplastic anemia 38 trials · 303 incl. sub-types Sub-types →
- Inherited aplastic anemia 2 trials · 53 incl. sub-types Sub-types →
- Idiopathic aplastic anemia 9 trials
- Myelophthisic anemia 0 trials
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Normocytic anemia 0 trials · 180 incl. sub-types
1 sub-type
- Hemolytic anemia 19 trials · 180 incl. sub-types Sub-types →
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Microcytic anemia 0 trials · 130 incl. sub-types
3 sub-types
- Hypochromic microcytic anemia 0 trials · 123 incl. sub-types Sub-types →
- Fetal erythroblastosis 7 trials
- IRIDA syndrome 0 trials
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Hypochromic anemia 0 trials · 123 incl. sub-types
1 sub-type
- Hypochromic microcytic anemia 0 trials · 123 incl. sub-types Sub-types →
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Beta-thalassemia and related diseases 0 trials · 99 incl. sub-types
7 sub-types
- Beta thalassemia 73 trials · 99 incl. sub-types Sub-types →
- Hemoglobin E-beta-thalassemia syndrome 5 trials
- Beta-thalassemia-X-linked thrombocytopenia syndrome 0 trials
- Delta-beta-thalassemia 0 trials
- Hemoglobin C-beta-thalassemia syndrome 0 trials
- Hemoglobin Lepore-beta-thalassemia syndrome 0 trials
- Hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 0 trials
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Congenital anemia 0 trials · 58 incl. sub-types
8 sub-types
- Fanconi anemia 29 trials · 42 incl. sub-types Sub-types →
- Congenital nonspherocytic hemolytic anemia 1 trial · 12 incl. sub-types Sub-types →
- Myopathy, lactic acidosis, and sideroblastic anemia 3 trials Sub-types →
- Congenital dyserythropoietic anemia type 1 1 trial Sub-types →
- Congenital dyserythropoietic anemia type 2 1 trial
- Congenital dyserythropoietic anemia type 3 0 trials
- Congenital dyserythropoietic anemia type 4 0 trials
- Severe congenital hypochromic anemia with ringed sideroblasts 0 trials
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Anemia due to chronic disorder 34 trials
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Pure red-cell aplasia 5 trials · 24 incl. sub-types
2 sub-types
- Diamond-Blackfan anemia 17 trials Sub-types →
- Adult pure red cell aplasia 2 trials
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Neonatal anemia 7 trials · 23 incl. sub-types
3 sub-types
- Twin to twin transfusion syndrome 14 trials Sub-types →
- Anemia of prematurity 4 trials
- Kernicterus due to isoimmunization 0 trials
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Deficiency anemia 3 trials · 16 incl. sub-types
3 sub-types
- Hereditary anemia 2 trials · 13 incl. sub-types Sub-types →
- Acquired deficiency anemia 0 trials Sub-types →
- Protein-deficiency anemia 0 trials
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Pancytopenia 15 trials
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Anemia due to enzyme disorder 1 trial · 14 incl. sub-types
4 sub-types
- Anemia due to erythrocyte enzyme disorder 0 trials · 13 incl. sub-types Sub-types →
- Gamma-glutamylcysteine synthetase deficiency 0 trials
- Glutathione synthetase deficiency without 5-oxoprolinuria 0 trials
- Hemolytic anemia due to erythrocyte adenosine deaminase overproduction 0 trials
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Sideroblastic anemia 0 trials · 14 incl. sub-types
3 sub-types
- Inherited sideroblastic anemia 2 trials · 7 incl. sub-types Sub-types →
- Myelodysplastic syndrome with ring sideroblasts 7 trials
- Pyridoxine-responsive sideroblastic anemia 0 trials
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Macrocytic anemia 0 trials · 11 incl. sub-types
2 sub-types
- Megaloblastic anemia 1 trial · 9 incl. sub-types Sub-types →
- Myelodysplastic syndrome associated with isolated del(5q) 2 trials
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Hemoglobin C disease 2 trials
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Hereditary methemoglobinemia 0 trials · 1 incl. sub-types
5 sub-types
- Methemoglobinemia type 4 1 trial
- Hemoglobin M disease 0 trials
- Methemoglobin reductase deficiency 0 trials
- Methemoglobinemia due to deficiency of methemoglobin reductase 0 trials
- Methemoglobinemia, alpha type 0 trials
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Hemoglobin D disease 0 trials
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Hemoglobin E disease 0 trials
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Hemoglobinopathy Toms River 0 trials
Most studied deeper sub-types
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New pill aims to boost red blood cells in MDS patients
Disease control Stopped earlyThis phase 2 trial tested a daily pill called etavopivat in 17 adults with very low, low, or intermediate risk MDS who had anemia. The goal was to see if the drug could improve red blood cell counts and reduce the need for transfusions. The study was terminated early, so the full…
Phase 2 • Sponsor: Forma Therapeutics, Inc. • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Can a pill replace EPO shots for anemia in kidney disease?
Disease control Stopped earlyThis trial is testing an experimental oral drug, GSK1278863, in people on dialysis who have anemia due to chronic kidney disease and who don't respond well to standard erythropoietin (EPO) injections. The goal is to see if the drug can raise or maintain hemoglobin levels within a…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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New anemia drug for MDS and myeloma patients shows early promise but trial halted
Disease control Stopped earlyThis study tested a daily pill called INCB000928 for people with anemia caused by myelodysplastic syndromes (MDS) or multiple myeloma. The goal was to see if it was safe and could raise red blood cell levels, reducing the need for transfusions. The trial was terminated early afte…
Phase 1/2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New blood gas device put to the test – but trial halted early
Diagnosis Stopped earlyThis study compared a new device, the Proxima 3®, to standard hospital equipment for measuring blood gases like oxygen and carbon dioxide. Researchers wanted to see if the new device was accurate and fast in patients whose condition was changing quickly. The trial was stopped ear…
Sponsor: Universitair Ziekenhuis Brussel • Aim: Diagnosis
Last updated Jun 27, 2026 07:58 UTC
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EPO blood pressure mystery: small study halted early
Knowledge-focused Stopped earlyThis study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…
Phase 2 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC