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Akinetic mutism
MONDO:0005640A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral frontal lobe dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)
Also known as: Coma vigilans (finding)
3 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsBroader categories
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Brain-wave test may predict who wakes up after severe brain injury
Knowledge-focused Not yet recruitingAfter a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…
Sponsor: Nicosia General Hospital • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Brain wave test may unlock hidden awareness in coma patients
Knowledge-focused Not yet recruitingThis study looks at whether an EEG (a brain wave test) can better tell the difference between people who are unresponsive but awake and those who show minimal signs of awareness after a severe brain injury. About 42 adults will take part. The goal is to see if brain responses to …
Sponsor: BDH-Klinik Hessisch Oldendorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC