ACTH-independent Cushing syndrome
MONDO:0020529A group of endogenous Cushing syndrome that may result from excess secretion of cortisol by either a unilateral and benign, or malignant adrenocortical tumor, or nodular adrenocortical disease.
Also known as: adrenal Cushing syndrome, adrenocorticotropic hormone-independent Cushing syndrome, corticotropin-independent Cushing syndrome
19 clinical trials for this condition and its sub-types.
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Broader categories
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New pill targets hormone imbalance from adrenal tumors
Disease control CompletedThis study tested a daily pill called SPI-62 in 30 adults with high cortisol levels caused by a non-cancerous adrenal tumor. The goal was to see if the drug could safely lower blood sugar and improve other health measures. Participants took 2 mg of SPI-62 each day for up to 12 we…
Phase: PHASE2 • Sponsor: Sparrow Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New drug aims to tame cortisol overload from adrenal tumors
Disease control CompletedThis Phase 3 trial tested a drug called relacorilant in 137 people with hypercortisolism caused by adrenal adenomas or hyperplasia. The goal was to see if it could improve blood sugar control and lower high blood pressure. Participants received either relacorilant or a placebo fo…
Phase: PHASE3 • Sponsor: Corcept Therapeutics • Aim: Disease control
Last updated Jun 26, 2026 14:09 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC