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ACTC1-related distal arthrogryposis with congenital heart disease

MONDO:0700352

A distal arthrogryposis caused by variation in the ACTC1 gene. This disease is characterised by multiple congenital contractures, neck pterygia, scoliosis, congenital heart defects, and/or cardiomyopathy.

67 clinical trials for this condition and its sub-types.

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Broader categories

Cardiovascular disorder (1051) Disease (680) Heart disorder (300) Congenital heart disease (248) Musculoskeletal system disorder (207) Hereditary disease (176) Muscle tissue disorder (56) Human disease (14) Developmental defect during embryogenesis (8) Congenital anomaly of cardiovascular system (5)
Trials to join now! 31 Not yet recruiting 6 Not yet finished but already full! 10 Completed 19 Terminated 1
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  • App-Based exercise program aims to strengthen hearts in congenital disease

    Disease control Terminated

    This study tests a remote, app-enabled exercise program designed for people aged 10 to 50 with congenital heart disease. Participants use a smartphone app with exercise modules and wearable devices to track heart rate and progress. The goal is to see if this approach can safely i…

    Phase: NA • Sponsor: Duke University • Aim: Disease control

    Last updated Aug 07, 2026 00:00 UTC

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