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127005 trials found · Page 5580 of 6351
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ICU Patients' hidden struggles: new study tracks anxiety and pain
Knowledge-focused CompletedEmotional distress is prevalent in ICU patients and may be influenced by physical symptoms such as dyspnea and pain, yet its evolution and interactions during ICU stay remain insufficiently explored. The main objective of this study is to investigate the trajectory of anxiety, sa…
Sponsor: Corporacion Parc Tauli • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:31 UTC
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New program boosts HIV prevention prescriptions in san francisco clinics
Prevention CompletedThe PrEP Optimization Intervention (PrEP-OI) aims to educate healthcare providers on PrEP and assist providers in the appropriate targeting of patients at increased risk for HIV acquisition, initiating PrEP when appropriate, and providing guidance on the ongoing monitoring and ad…
Sponsor: University of California, San Francisco • Aim: Prevention
Last updated Jun 26, 2026 18:10 UTC
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Gentle group workouts may ease joint pain without drugs
Symptom relief Recruiting nowThe primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health consults.
Sponsor: University of Missouri-Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Mayo clinic launches IBD biobank to unlock disease secrets
Knowledge-focused By invitation onlyResearchers are collecting and storing blood, stool, and urine samples and medical information to better understand Inflammatory Bowel Disease (IBD) to improve disease outcome.
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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New study aims to make anesthesia safer for kids with rare neck condition
Knowledge-focused OngoingKlippel-Feil syndrome (KFS) was first described in 1912 by Klippel and Feil as a classic triad are comprised of a short neck, a low posterior hairline and restricted motion of the neck. This disease is considered as one of the congenital causes of difficult airway with the incide…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Brain oxygen mystery: 1,000 kids to help unlock Anesthesia's hidden effects
Knowledge-focused Recruiting nowThis is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical ane…
Sponsor: Children's Hospital Los Angeles • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Tourniquets before hospital: help or hype?
Knowledge-focused Completed2.1. Objective: • Primary Objective: To compare outcomes of patients with extremity injuries presenting with or without pre-hospital tourniquet placement. 2.2. Study Outcome Measures * Primary Outcome: Incidence of arrival in shock (SBP \<90) * Secondary Outcomes: Demographics…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Jaw pain and mental health: study probes the hidden link
Knowledge-focused By invitation onlyThe aim of the study was to asses levels and relationship of chronic pain, anxiety, depression and perceived stress in TMD patients .
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Jul 12, 2026 00:00 UTC
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Sleep Apnea's hidden danger: low oxygen may fuel diabetes risk
Knowledge-focused CompletedObstructive sleep apnea (OSA) is a common condition associated with significant adverse health outcomes. Our overarching hypothesis is that patients with OSA and hypoxia (H-OSA) have greater degrees of insulin resistance in both liver and adipose tissue when compared to those wit…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Could a skin gel help fight breast cancer? early trial tests endoxifen
Disease control OngoingThis randomized phase I trial studies the side effects and best dose of endoxifen hydrochloride in treating participants who are undergoing breast surgery. Endoxifen hydrochloride may treat or reduce the risk of breast cancer.
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Heart attack patients get a closer look: MRI study aims to sharpen prognosis
Knowledge-focused OngoingThe goal of this observational study is to evaluate the clinical utility of cardiac magnetic resonance (CMR) in patients with acute myocardial infarction (AMI). This is a retrospective and prospective cohort study that has already enrolled a number of patients and will continue t…
Sponsor: The Affiliated Hospital of Xuzhou Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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New registry tracks STABILISE procedure for aortic tears
Knowledge-focused OngoingThe aim of the study is to evaluate results of patients treated with the STABILISE technique for acute/subacute aortic dissection. Results and postoperative events are reported in accordance with the current reporting standards for endovascular aortic repair prepared and revised …
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Extra Zzz's may boost metabolism in obesity
Knowledge-focused CompletedThis study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed in order to achieve \>7h sleep/night (sleep extension; n=15) while the other half wil…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Can Over-the-Counter painkillers replace opioids after knee surgery?
Symptom relief Recruiting nowThe purpose of this study is to look at pain management with opioids versus non-opioids after knee arthroscopy. This study will determine 1) whether the most commonly used non-narcotic medications provide pain relief comparable with the most commonly prescribed narcotic medicatio…
Phase 4 • Sponsor: Sanford Health • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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New study aims to take the guesswork out of Kids' pain treatment
Knowledge-focused Recruiting nowIt is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need. According to the American Medical Association, "the pediatric population is at risk of inadequate pain management, with age-related fa…
Sponsor: Julia Finkel • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Scientists probe immune Cells' role in skin scarring disease
Knowledge-focused CompletedB Lymphocytes are thought to play an important role in the pathophysiology of systemic sclerosis. In this study, the profibrosing role of B lymphocytes of patients with systemic sclerosis will be evaluated.
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Italy launches massive genetic database to match cancer patients with better treatments
Knowledge-focused OngoingThe goal of this observational study is the creation of a national network of precision medicine, which allows to increase, for Italian patients suffering from solid tumors, the possibility of access to more innovative therapies and to collect retrospectively their clinical data.…
Sponsor: Federation of Italian Cooperative Oncology Groups • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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New imaging technique aims to make lymph node biopsies safer and more accurate
Knowledge-focused Stopped earlyTo perform image-guided laparoscopic intra-abdominal lymph node biopsy with goal of minimizing surgical risk and improving accuracy of biopsy.
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Wireless EEG headsets reveal Brain's journey into anesthesia
Knowledge-focused CompletedPropoStatus is a prospective observational study investigating the EEG changes seen in neurologically healthy patients during induction of general anesthesia with propofol.
Sponsor: University of Oulu • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Honey heals: sweet solution may beat standard ointment for hearing aid skin woes
Prevention CompletedPostoperative medicinal grade honey in post-operative care may prevent bone anchored hearing aid associated skin breakdown better than standard care of bacitracin ointment alone in adult patients.
Phase 4 • Sponsor: Henry Ford Health System • Aim: Prevention
Last updated Jun 27, 2026 08:09 UTC