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116076 trials found · Page 4478 of 5804
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Everyday people also struggle with balance after ACL surgery, study finds
Knowledge-focused CompletedAnterior cruciate ligament (ACL) injuries are among the most frequent knee injuries, often leading to deficits in postural stability and balance as a result of mechanoreceptor damage, which disrupts proprioceptive feedback and sensorimotor regulation. The present study aimed to p…
Sponsor: Nigde Omer Halisdemir University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Heart rehab gets smarter: machine learning tailors exercise to your nerves
Knowledge-focused ENROLLING_BY_INVITATIONCardiac rehabilitation (CR) is an essential secondary prevention component in the treatment of cardiovascular diseases and one of the most cost- effective clinical interventions. Exercise training (ET) in CR programs (CRP) has unequivocal benefits in the reduction of cardiovascul…
Sponsor: Instituto Politécnico de Leiria • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Scientists probe why belly fat acts differently in obesity
Knowledge-focused Recruiting nowAdults who gain most of their excess weight in the abdominal area typically do not respond to factors that "turn on" fat cells the same way as people who don't have excessive weight. Researchers are trying to understand why fat tissue responds differently in people with different…
Phase: EARLY_PHASE1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Doctors get report cards on antibiotic use in urgent care
Knowledge-focused OngoingMany clinicians prescribe antibiotics for patients with acute respiratory infections even when antibiotics will not benefit the patient because the infection is due to a virus. To discourage this type of unnecessary antibiotic use, the investigators will assess whether it is help…
Phase: NA • Sponsor: Daniel Livorsi • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Sniffing geranium oil may ease chemo sickness
Symptom relief CompletedChemotherapy-induced nausea and vomiting (CINV) remain among the most distressing side effects experienced by cancer patients and can significantly affect treatment tolerance and quality of life. Geranium essential oil has been proposed as a complementary, non-pharmacological the…
Phase: NA • Sponsor: Universitas Muhammadiyah Surakarta • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Sound waves could spot nerve injuries in broken arms before surgery
Diagnosis Recruiting nowThis study investigates how well ultrasound imaging can identify damage to the radial nerve in patients with a broken upper arm bone (humeral shaft fracture). Some of these patients also have weakness or paralysis in their hand and wrist due to injury to the radial nerve. The stu…
Sponsor: Istanbul Medeniyet University • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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Computer models aim to predict deadly infections in fragile newborns
Knowledge-focused CompletedBehind the scenes pilot trial in the computer lab involving chart review to use neonatal intensive care unit data to create computer models predicting sepsis and necrotizing enterocolitis in very small premature infants
Sponsor: University of Virginia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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New dental implant technique aims to save bone and gum shape
Disease control CompletedBackground: Immediate implant placement has become a routine and regular clinical practice. When the labial bone plate develops a dehiscence-type defect, delayed implant placement was recommended to give suitable amount of time for soft tissue thickening. However, it has a number…
Phase: NA • Sponsor: Alexandria University • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Needle-Free migraine relief for kids? nasal spray cocktail tested in ER
Symptom relief TerminatedThe purpose of this study is to determine if intranasal (IN) Ketorolac in combination with oral Prochlorperazine and Diphenhydramine is non-inferior to current migraine management which involves use of intravenous (IV) Ketorolac and oral adjuncts Prochlorperazine and diphenhydram…
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Tailored implants boost jaw surgery precision
Disease control CompletedThis study will evaluate the patient specific surgical stent and plate for guided reduction and fixation of mandibular angle fractures.
Phase: PHASE4 • Sponsor: Alexandria University • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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3D skull models calm nerves before jaw surgery, study finds
Symptom relief CompletedThis study evaluates whether adding visual tools to standard preoperative counseling can reduce anxiety in patients scheduled for bimaxillary orthognathic surgery. Participants aged 18-36 years undergoing elective surgery was randomly assigned to one of three groups: (1) standard…
Phase: NA • Sponsor: Ankara University • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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Which anesthesia is safer for frail Seniors' hearts during scopes?
Knowledge-focused Recruiting nowThis study aims to compare the effects of conscious sedation and intravenous general anesthesia on cardiovascular events in frail patients undergoing digestive endoscopy diagnosis and treatment.
Phase: NA • Sponsor: Beijing Friendship Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Fatty liver study tracks 922 patients to uncover hidden risks
Knowledge-focused CompletedThis longitudinal cohort study will enroll individuals with MASLD (and/or those at risk) and follow them over time to identify clinical and metabolic risk factors for disease progression and to evaluate predictors of long-term outcomes, including fibrosis progression and liver-re…
Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Tiny hand nerves may hold key to Dupuytren's return
Knowledge-focused Recruiting nowDupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions. Finger movement can be restored by surgery (removing the fibrosis ti…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Which nerve block eases shoulder surgery pain best?
Symptom relief OngoingThe Importance of Postoperative Analgesia in Shoulder Surgery Shoulder surgery is an orthopedic procedure that can be performed either through open surgery or arthroscopically. Pain following shoulder surgery can lead to adverse outcomes such as decreased functional status, incr…
Sponsor: Aydin Adnan Menderes University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Brain scans probe Serotonin's role in Parkinson's pain
Knowledge-focused Recruiting nowThis project will explore the involvement of the serotonin system in the pathophysiology of PD-related central pain. Thus, the serotonin system will be evaluated in PD patients with and without central pain who will benefit from brain positron emission tomography (PET) allowing i…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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New surgical twist may speed healing of anal fistulas
Disease control CompletedThis study evaluated two sphincter-preserving surgical techniques for transsphincteric anal fistula: standard ligation of the intersphincteric fistula tract (LIFT) and modified LIFT via a lateral approach. Adult patients with MRI-confirmed transsphincteric anal fistula were rando…
Phase: NA • Sponsor: Tugberk Tok • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Brain training without moving: new study hopes to unlock stroke recovery
Knowledge-focused Recruiting nowThis study focuses on electromyographic analysis of upper limb muscle activation in stroke survivors during Motor Imagery (MI) and Action Observation (AO) rehabilitation techniques. By measuring muscle activity in the wrist and finger flexors and extensors, the research seeks to …
Phase: NA • Sponsor: University of Salamanca • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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New app aims to make chemsex safer for gay men
Knowledge-focused CompletedThis study is examining the usability and effectiveness of an innovative mobile app that integrates harm reduction strategies into the existing pre-exposure prophylaxis (PrEP) intake and adherence app, with an overarching goal to reduce the potentially negative consequences of pr…
Phase: NA • Sponsor: National Cheng Kung University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Brain health bootcamp: VA tests 20-Week program for aging veterans
Knowledge-focused OngoingThe purpose of this study is to learn about the effects of AgeWISE-Action Plan (AgeWISE-AP), a 20-week program designed to provide education and individualized planning with a goal of improving brain health.
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC