New hope for blood cancer: targeted therapy combo shows promise in phase 2 trial
NCT ID NCT06890884
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 13 times
Summary
This study tests whether a new drug, zilovertamab vedotin, combined with standard chemotherapy (R-CHP) works better than another approved drug combo for people with a specific type of fast-growing blood cancer called GCB diffuse large B-cell lymphoma. About 594 adults who have not had treatment before will take part. The main goal is to see if the cancer completely disappears after treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 594 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2025
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Has histologically confirmed diagnosis of germinal center B-cell (GCB) subtype of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, according to the World Health Organization (WHO) classification of neoplasms of the hematopoietic and lymphoid tissues. * Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale. * Has received no prior treatment for their DLBCL. * Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART). * Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization. * Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening. Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has a history of transformation of indolent disease to DLBCL. * Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma. * Has Ann Arbor Stage I DLBCL. * Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (\<6 months prior to enrollment), myocardial infarction (\<6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication. * Has clinically significant pericardial or pleural effusion. * Has ongoing Grade \>1 peripheral neuropathy. * Has a demyelinating form of Charcot-Marie-Tooth disease. * HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease. * Has ongoing corticosteroid therapy. * Known additional malignancy that is progressing or has required active treatment within the past 2 years. * Known active central nervous system (CNS) lymphoma. * Has active autoimmune disease that has required systemic treatment in the past 2 years. * Has active infection requiring systemic therapy. * Has active HBV (defined as HBsAg positive and detectable HBV deoxyribonucleic acid (DNA)) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection. * Has history of stem cell/solid organ transplant.
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Get notified about this study
Sign up to get updates when this study changes or when new studies for Germinal center B-cell subtype diffuse large B-cell lymphoma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
142 sites in 9 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
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Contact
Email: •••••@•••••
Locations
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AIDPORT Sp. z o.o. ( Site 0808)
RECRUITINGSkórzewo, Greater Poland Voivodeship, 60-185, Poland
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AZ Delta ( Site 0303)
RECRUITINGRoeselare, West-Vlaanderen, 8800, Belgium
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AZ Sint Jan Brugge-Oostende ( Site 0308)
RECRUITINGBruges, West-Vlaanderen, 8000, Belgium
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AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306)
RECRUITINGMechelen, Antwerpen, 2800, Belgium
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Abramson Cancer Center and Perelman Center for Advanced Medicine ( Site 0131)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Aichi Cancer Center ( Site 1007)
RECRUITINGNagoya, Aichi-ken, 464-8681, Japan
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Alliance Cancer Specialists (ACS) ( Site 8010)
RECRUITINGSellersville, Pennsylvania, 18960, United States
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Arcispedale Santa Maria Nuova ( Site 0706)
RECRUITINGReggio Emilia, 42123, Italy
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Atlantic Health Morristown Medical Center ( Site 0163)
RECRUITINGMorristown, New Jersey, 07960, United States
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Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702)
RECRUITINGPalermo, Sicily, 90146, Italy
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Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703)
RECRUITINGAlessandria, 15121, Italy
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Baptist Health Hardin ( Site 0154)
RECRUITINGElizabethtown, Kentucky, 42701, United States
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Baptist Health Lexington ( Site 0127)
RECRUITINGLexington, Kentucky, 40503, United States
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Baptist MD Anderson Cancer Center ( Site 0176)
RECRUITINGJacksonville, Florida, 32207, United States
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Bass Medical Group ( Site 0123)
RECRUITINGWalnut Creek, California, 94598, United States
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Beacon Cancer Care ( Site 0142)
RECRUITINGPost Falls, Idaho, 83854, United States
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Beth Israel Deaconess Medical Center ( Site 0161)
RECRUITINGBoston, Massachusetts, 02215, United States
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Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130)
RECRUITINGBoca Raton, Florida, 33486, United States
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Bozeman Health Deaconess Hospital ( Site 0183)
RECRUITINGBozeman, Montana, 59715, United States
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Bristol Haematology and Oncology Centre ( Site 0908)
RECRUITINGBristol, Bristol, City of, BS2 8ED, United Kingdom
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Cancer Care Associates Of York ( Site 0174)
RECRUITINGYork, Pennsylvania, 17403, United States
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Centrum für Hämatologie und Onkologie Bethanien ( Site 0417)
RECRUITINGFrankfurt am Main, Hesse, 60389, Germany
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Christie Hospital NHS Trust ( Site 0901)
RECRUITINGManchester, M20 4BX, United Kingdom
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Churchill Hospital ( Site 0903)
RECRUITINGOxford, Oxfordshire, OX3 7LJ, United Kingdom
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City of Hope - Phoenix ( Site 0202)
RECRUITINGGoodyear, Arizona, 85338, United States
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City of Hope Comprehensive Cancer Center ( Site 0191)
RECRUITINGDuarte, California, 91010, United States
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Clatterbridge Cancer Centre - Liverpool ( Site 0911)
RECRUITINGLiverpool, L7 8YA, United Kingdom
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Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199)
RECRUITINGMayfield Heights, Ohio, 44124, United States
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Cleveland Clinic Main ( Site 0101)
RECRUITINGCleveland, Ohio, 44195, United States
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Cliniques Universitaires Saint-Luc ( Site 0302)
RECRUITINGBrussels, Bruxelles-Capitale, Region de, 1200, Belgium
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Colorado West Healthcare System-Grand Valley Oncology ( Site 0165)
RECRUITINGGrand Junction, Colorado, 81505, United States
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Dana Farber Cancer Institute ( Site 0111)
RECRUITINGBoston, Massachusetts, 02215, United States
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Dietrich Bonhoeffer Klinikum-Neubrandenburg ( Site 0439)
RECRUITINGNeubrandenburg, Mecklenburg-Vorpommern, 17036, Germany
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Edith Wolfson Medical Center ( Site 0602)
RECRUITINGHolon, 5810001, Israel
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Erie County Medical Center ( Site 0175)
COMPLETEDBuffalo, New York, 14215, United States
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Fairview Hospital-Moll Cancer Center ( Site 0198)
RECRUITINGCleveland, Ohio, 44111, United States
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Fujita Health University Hospital ( Site 1003)
RECRUITINGToyoake, Aichi-ken, 470-1192, Japan
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Genesis Cancer and Blood Institute ( Site 0193)
RECRUITINGHot Springs, Arkansas, 71913, United States
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Georgetown University Medical Center ( Site 0117)
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Guy s & St Thomas NHS Foundation Trust ( Site 0904)
RECRUITINGLondon, London, City of, SE1 9RT, United Kingdom
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HELIOS Klinikum Wuppertal ( Site 0435)
RECRUITINGWuppertal, North Rhine-Westphalia, 42283, Germany
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Haddasah Medical Center ( Site 0601)
RECRUITINGJerusalem, 9112001, Israel
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Hammersmith Hospital ( Site 0915)
RECRUITINGLondon, London, City of, W12 0 HS, United Kingdom
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Hokkaido University Hospital ( Site 1004)
RECRUITINGSapporo, Hokkaido, 060-8648, Japan
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Hopital de Jolimont ( Site 0304)
RECRUITINGHaine-Saint-Paul, Hainaut, 7100, Belgium
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0707)
RECRUITINGMeldola, Forli-Cesena, 47014, Italy
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Illinois Cancer Care ( Site 7005)
RECRUITINGPeoria, Illinois, 61615, United States
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Infirmary Cancer Care ( Site 0157)
RECRUITINGMobile, Alabama, 36607, United States
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Intermountain Healthcare - St. George ( Site 0203)
RECRUITINGSt. George, Utah, 84790, United States
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Intermountain Medical Center ( Site 0182)
RECRUITINGMurray, Utah, 84107, United States
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Ironwood Cancer & Research Centers ( Site 0204)
RECRUITINGChandler, Arizona, 85224, United States
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Istituto Clinico Humanitas ( Site 0704)
RECRUITINGRozzano, Milano, 20089, Italy
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Istituto Europeo di Oncologia ( Site 0701)
RECRUITINGMilan, 20141, Italy
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Johanniter Krankenhaus Bonn ( Site 0440)
RECRUITINGBonn, North Rhine-Westphalia, 53113, Germany
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KRH Klinikum Siloah ( Site 0441)
RECRUITINGHanover, Lower Saxony, 30459, Germany
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Kansai Medical University Hospital ( Site 1006)
RECRUITINGHirakata, Osaka, 573-1191, Japan
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Klinikum Chemnitz gGmbH ( Site 0405)
RECRUITINGChemnitz, Saxony, 09113, Germany
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Klinikum Kassel GmbH ( Site 0434)
RECRUITINGKassel, Hesse, 34125, Germany
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Klinikum Stuttgart. Klinik fur Hamatologie. Onkologie. Palliativmedizin und Stammzelltransplantation ( Site 0419)
RECRUITINGStuttgart, Baden-Wurttemberg, 70174, Germany
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LMU Klinikum ( Site 0428)
RECRUITINGMunich, Bavaria, 81377, Germany
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Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108)
RECRUITINGNew York, New York, 10016, United States
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Lincoln County Hospital ( Site 0906)
RECRUITINGLincoln, Lincolnshire, LN2 5QY, United Kingdom
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Louisiana State University Health Sciences Shreveport ( Site 0195)
RECRUITINGShreveport, Louisiana, 71103, United States
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Mater Misercordiae University Hospital ( Site 0501)
RECRUITINGDublin, D07 R2WY, Ireland
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Medical College of Wisconsin ( Site 0103)
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants (MOHC) ( Site 8007)
RECRUITINGNewark, Delaware, 19713, United States
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Medical University of South Carolina ( Site 0153)
RECRUITINGCharleston, South Carolina, 29425, United States
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Mid Florida Hematology and Oncology Center ( Site 0152)
RECRUITINGOrange City, Florida, 32763, United States
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Minnesota Oncology Hematology (MNO) ( Site 8004)
RECRUITINGBurnsville, Minnesota, 55337, United States
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Mission Blood & Cancer Care ( Site 0114)
RECRUITINGWaukee, Iowa, 50263, United States
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Mount Sinai Braman Comprehensive Cancer Center ( Site 0140)
RECRUITINGMiami Beach, Florida, 33140, United States
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NHO Revive Research Institute, LLC ( Site 0121)
RECRUITINGLincoln, Nebraska, 68506, United States
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Nagasaki University Hospital ( Site 1008)
RECRUITINGNagasaki, 852-8501, Japan
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803)
RECRUITINGWarsaw, Masovian Voivodeship, 02-781, Poland
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National Cancer Center Hospital ( Site 1009)
RECRUITINGChūō, Tokyo, 104-0045, Japan
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National Hospital Organization Sendai Medical Center ( Site 1005)
RECRUITINGSendai, Miyagi, 983-8520, Japan
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Nippon Medical School Hospital ( Site 1001)
RECRUITINGBunkyo, Tokyo, 113-8603, Japan
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Northwest Cancer Specialists (Compass Oncology) ( Site 8000)
RECRUITINGVancouver, Washington, 98684, United States
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Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185)
RECRUITINGLouisville, Kentucky, 40207, United States
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Novant Health Forsyth Medical Center ( Site 0206)
RECRUITINGWinston-Salem, North Carolina, 27103, United States
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Novant Health Presbyterian Medical Center ( Site 0177)
RECRUITINGCharlotte, North Carolina, 28204, United States
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Ochsner Clinic Foundation ( Site 0189)
RECRUITINGNew Orleans, Louisiana, 70121, United States
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Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0209)
RECRUITINGMonroe, Louisiana, 71202, United States
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Optum Medical Care, PC ( Site 0122)
RECRUITINGWestbury, New York, 11590, United States
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Otto-Von-Guericke-Universitaet Magdeburg ( Site 0411)
RECRUITINGMagdeburg, Saxony-Anhalt, 39120, Germany
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Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180)
RECRUITINGBaton Rouge, Louisiana, 70808, United States
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Palo Verde Cancer Specialists ( Site 0105)
RECRUITINGGlendale, Arizona, 85304, United States
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Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208)
RECRUITINGMineola, New York, 11501, United States
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Pratia MCM Krakow ( Site 0804)
RECRUITINGKrakow, Lesser Poland Voivodeship, 30-727, Poland
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Pratia Onkologia Katowice ( Site 0801)
RECRUITINGKatowice, Silesian Voivodeship, 40-519, Poland
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Providence Oncology and Hematology Clinic Westside ( Site 0179)
RECRUITINGPortland, Oregon, 97225, United States
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Providence Portland Medical Center ( Site 0120)
RECRUITINGPortland, Oregon, 97213, United States
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Queen Elizabeth Hospital Birmingham ( Site 0912)
RECRUITINGBirmingham, B15 2TH, United Kingdom
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Rabin Medical Center ( Site 0607)
RECRUITINGPetah Tikva, 4941492, Israel
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Rambam Health Care Campus ( Site 0604)
RECRUITINGHaifa, 3109601, Israel
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Rocky Mountain Cancer Centers (RMCC) ( Site 8001)
RECRUITINGAurora, Colorado, 80012, United States
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Roswell Park Cancer Institute ( Site 0192)
RECRUITINGBuffalo, New York, 14263, United States
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Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135)
RECRUITINGBurbank, California, 91505, United States
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Royal Devon & Exeter Hospital ( Site 0910)
RECRUITINGExeter, Devon, EX2 5DW, United Kingdom
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SCRI Oncology Partners ( Site 7002)
RECRUITINGNashville, Tennessee, 37203, United States
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SSM Health Dean Medical Group ( Site 0106)
RECRUITINGMadison, Wisconsin, 53715, United States
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SUNY Upstate Cancer Center ( Site 0178)
RECRUITINGSyracuse, New York, 13210, United States
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Saint Elizabeth Medical Center Edgewood ( Site 0141)
RECRUITINGEdgewood, Kentucky, 41017, United States
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Sheba Medical Center ( Site 0603)
RECRUITINGRamat Gan, 5265601, Israel
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Shimane University Hospital ( Site 1002)
RECRUITINGIzumo, Shimane, 693-8501, Japan
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Soroka Medical Center ( Site 0606)
RECRUITINGBeersheba, 8410101, Israel
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Sourasky Medical Center ( Site 0608)
RECRUITINGTel Aviv, 6423906, Israel
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Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 0807)
RECRUITINGWałbrzych, Lower Silesian Voivodeship, 58-309, Poland
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St Vincent's University Hospital ( Site 0502)
RECRUITINGDublin, Dublin, D04 T6F4, Ireland
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St. James's Hospital ( Site 0505)
RECRUITINGDublin, D08 E9P6, Ireland
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Stoke Mandeville Hospital ( Site 0917)
RECRUITINGAylesbury, Buckinghamshire, HP21 8AL, United Kingdom
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Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806)
RECRUITINGNowy Sącz, Lesser Poland Voivodeship, 33-300, Poland
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Temple University Hospital ( Site 0133)
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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Tennessee Cancer Specialists ( Site 7004)
RECRUITINGKnoxville, Tennessee, 37909, United States
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Texas Oncology - Central/South Texas ( Site 8006)
RECRUITINGAustin, Texas, 78705, United States
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Texas Oncology - Northeast Texas ( Site 8002)
RECRUITINGPalestine, Texas, 75801, United States
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Texas Oncology - San Antonio ( Site 8009)
RECRUITINGSan Antonio, Texas, 78240, United States
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Texas Oncology - West Texas ( Site 8008)
RECRUITINGAmarillo, Texas, 79124, United States
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The James Cook University Hospital ( Site 0909)
RECRUITINGMiddlesbrough, England, TS4 3BW, United Kingdom
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The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145)
COMPLETEDTyler, Texas, 75701, United States
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UT Southwestern Medical Center ( Site 0190)
RECRUITINGDallas, Texas, 75390, United States
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UZ Leuven ( Site 0301)
RECRUITINGLeuven, Vlaams-Brabant, 3000, Belgium
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Uniklinik Erlangen ( Site 0412)
RECRUITINGErlangen, Bavaria, 91054, Germany
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Universita degli Studi di Napoli Federico II ( Site 0705)
RECRUITINGNaples, 80131, Italy
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UniversitaetsklInikum Tuebingen ( Site 0410)
RECRUITINGTübingen, Baden-Wurttemberg, 72076, Germany
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Universitaetsklinikum Schleswig-Holstein - Campus Luebeck ( Site 0425)
RECRUITINGLübeck, Schleswig-Holstein, 23562, Germany
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Universitaetsklinikum Ulm. ( Site 0404)
RECRUITINGUlm, Baden-Wurttemberg, 89081, Germany
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Universitaetsklinikum Wuerzburg ( Site 0401)
RECRUITINGWürzburg, Bavaria, 97080, Germany
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University Hospital Limerick ( Site 0503)
RECRUITINGLimerick, V94 F858, Ireland
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University Hospitals Plymouth NHS Trust ( Site 0905)
RECRUITINGPlymouth, Devon, PL68DH, United Kingdom
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University Hospitals of Cleveland ( Site 0155)
RECRUITINGCleveland, Ohio, 44106, United States
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University Of Nebraska Medical Center ( Site 0110)
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Chicago Medical Center ( Site 0126)
RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati Medical Center ( Site 0156)
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Iowa-Holden Comprehensive Cancer Center ( Site 0139)
RECRUITINGIowa City, Iowa, 52242, United States
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University of North Carolina Medical Center ( Site 0136)
RECRUITINGChapel Hill, North Carolina, 27514, United States
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Universitätsklinikum Aachen ( Site 0418)
RECRUITINGAachen, North Rhine-Westphalia, 52074, Germany
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Universitätsklinikum Jena ( Site 0438)
RECRUITINGJena, Thuringia, 07747, Germany
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Uniwersyteckie Centrum Kliniczne ( Site 0802)
RECRUITINGGdansk, Pomeranian Voivodeship, 80-214, Poland
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VCU Health Adult Outpatient Pavillion ( Site 0138)
RECRUITINGRichmond, Virginia, 23219, United States
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VITAZ ( Site 0307)
RECRUITINGSint-Niklaas, Oost-Vlaanderen, 9100, Belgium
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Valley Health Systems - Ridgewood Campus ( Site 0125)
RECRUITINGParamus, New Jersey, 07652, United States
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Virginia Cancer Specialists, PC ( Site 8003)
RECRUITINGManassas, Virginia, 20110, United States
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ZIV Medical Center ( Site 0605)
RECRUITINGSafed, 13100, Israel
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