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Promising combo tackles Hard-to-Treat brain cancer

NCT ID NCT05681195

First seen Mar 04, 2026 · Last updated Jun 17, 2026 · Updated 17 times

Summary

This study tests a combination of two drugs, zanubrutinib and pemetrexed, followed by zanubrutinib alone, in people whose central nervous system lymphoma has returned or stopped responding to treatment. The goal is to see if this approach can shrink tumors and control the disease. About 15 adults with primary or secondary CNS lymphoma will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Miami Cancer Institute at Baptist Health, Inc.

    RECRUITING

    Miami, Florida, 33176, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

neoplasm primary central nervous system lymphoma Recurrence refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.