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New injection aims to ease Post-Surgery pain without Morphine's downsides

NCT ID NCT06890533

Symptom relief Sponsor: Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This phase 3 trial tests an experimental painkiller called YZJ-4729 for people experiencing moderate to severe pain after abdominal surgery. Participants receive either YZJ-4729, a placebo (saline), or morphine, and researchers measure pain intensity over 24 hours. The goal is to see if YZJ-4729 works well and is safe compared to standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
YZJ-4729 tartrate injection
What this could lead to
If successful, this could provide a new painkiller option for people recovering from abdominal surgery, potentially with fewer side effects than morphine.
What could go wrong
This is an early-phase trial, so the drug may not prove more effective or safer than existing treatments. Side effects typical of opioids are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 560 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Be able to understand the study purpose and cooperate with the study procedures of this trial, voluntarily provide written informed consent 2. Body mass index (BMI) ≥18 kg/m2 and ≤28 kg/m2. 3. ASA I - II 4. Experiences a pain intensity rating of moderate to severe acute pain following abdominal surgery, with a pain intensity score of ≥4 on a Numeric Rating Scale (NRS) within 4 hours post-surgery Exclusion Criteria: 1. Allergy to opioids and other medications that may be used during the trial. 2. Nervous system disorders (e.g. epilepsy) 3. Psychiatric disorders (e.g. depression) 4. History of difficult airways 5. Random blood glucose ≥11.1 mmol/L 6. Uncontrolled blood pressure \[e.g., hypertension (systolic blood pressure ≥160 mmHg, diastolic blood pressure ≥100 mmHg)，or hypotension(systolic blood pressure \<90 mmHg)\] 7. Abnormal pulse oxygen saturation (SpO2 \<90 %) 8. Abnormal liver function or renal function 9. Used agents that could affect the analgesic response 10. Used agents that could affect drug metabolism 11. Has previously participated in another YZJ-4729 clinical study

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

Contacts and locations

Locations

  • Affiliated Hospital of Jiangnan University

    Wuxi, China

  • Affiliated Zhongshan Hospital of Dalian University

    Dalian, China

  • Cangzhou Central Hospital

    Cangzhou, China

  • Cangzhou People's Hospital

    Cangzhou, China

  • Changde First People's Hospital

    Changde, China

  • Changsha Hospital Affiliated to Hunan University

    Changsha, China

  • Deyang People's Hospital

    Deyang, China

  • Dongguan People's Hospital

    Dongguan, China

  • Ganzhou People's Hospital

    Ganzhou, China

  • Guangdong Province Traditional Chinese Medical Hospital

    Guangzhou, China

  • Haikou People's Hospital

    Haikou, China

  • Henan Provincial People's Hospital

    Zhengzhou, China

  • Huzhou Central Hospital

    Huzhou, China

  • JiangXi Provincial People's Hospital

    Nanchang, China

  • Liuzhou People's Hospital

    Liuzhou, China

  • Liuzhou Workers' Hospital

    Liuzhou, China

  • Luoyang Central Hospital

    Luoyang, China

  • Ma'anshan People's Hospital

    Ma’anshan, China

  • Mianyang Central Hospital

    Mianyang, China

  • Ningbo Medical Center Lihuili Hospital

    Ningbo, China

  • Qingdao Central Hospital of Rehabilitation University

    Qingdao, China

  • Shanghai First Maternity and Infant Hospital

    Shanghai, China

  • Shanghai Fourth People's Hospital

    Shanghai, China

  • Sichuan Provincial People's Hospital

    Chengdu, China

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen University

    Guangzhou, China

  • Taizhou People's Hospital

    Taizhou, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, China

  • The First Affiliated Hospital of Jinan University

    Guangzhou, China

  • The First Affiliated Hospital of University of South China

    Hengyang, China

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, China

  • The First Hospital of Jiaxing

    Jiaxing, China

  • The First Hospital of Jilin University

    Ch’ang-ch’un, China

  • The First People's Hospital of Guangyuan

    Guangyuan, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    Ha’erbin, China

  • The Fourth Hospital OF Changsha

    Changsha, China

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, China

  • The Second Hospital of Tianjin Medical University

    Tianjin, China

  • The Second Nanning People's Hospital

    Nanning, China

  • The Second People's Hospital of Chengdu

    Chengdu, China

  • The Second People's Hospital of Hefei

    Hefei, China

  • The Second People's Hospital of Neijiang

    Neijiang, China

  • The Second People's Hospital of Yibin

    Yibin, China

  • The Third People's Hospital of Chengdu

    Chengdu, China

  • The Third Xiangya Hospital of Central South University

    Changsha, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, China

  • Wuhan Third Hospital

    Wuhan, China

  • Zhangzhou Municipal of Fujian Province

    Zhangzhou, China

  • Zhongshan Hospital Xiamen University

    Xiamen, China

  • Zhuzhou Central Hospital

    Zhuzhou, China

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