Xenon gas MRI: a safer way to see inside lungs and brain?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects male and female aged 18-75 * Subject has a smoking history of ≤ 1 pack year * Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent * Subject must be able to perform a breath hold for 16 seconds * Subject has a Body Mass Index (BMI) between 18 and 40 * Subject is judged to be in stable health on the basis of medical history * Subject able to perform reproducible pulmonary function tests (i.e., the 3 best acceptable spirograms have Forced Expiratory Volume (FEV1) values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater) Exclusion Criteria: * Subject is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material * Subject has a history of chronic or acute respiratory disease * Subject has a history of cardiovascular disorders including coronary insufficiency, cardiac arrhythmias, severe hypertension (≥160 over ≥100) * Subject has a daytime room air oxygen saturation ≤ 92% ± 2% while supine * Subject is unable to perform spirometry or plethysmography maneuvers * Subject is pregnant or lactating * In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia * Subject has an MRI incompatible device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants)