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Friendly mosquitoes take a bite out of dengue in landmark trial

NCT ID NCT04514107

Prevention Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a clever way to prevent dengue fever: releasing mosquitoes infected with Wolbachia bacteria into neighborhoods in Brazil. Over four years, researchers compared areas that got these special mosquitoes plus usual control methods to areas with usual methods alone. The goal was to see if the Wolbachia mosquitoes could lower the number of new infections in children aged 6-11. The approach aims to stop disease before it starts, not treat it after.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

5,757 people

The number who actually took part.

Started

Sep 2020

Finished

Oct 2024

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 11 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Children aged 6-11 years at enrollment. 2. Child's parent or legal guardian agrees to provide written informed consent. 3. Child agrees to provide informed assent. 4. Child is enrolled in a public school selected for this trial (and which define the clusters). 5. Child resides within geographic boundaries at least 5 days a week in the cluster area corresponding to his/her school. Exclusion Criteria: 1. Children planning to move outside of the cluster boundary within the study period. 2. Child has poor venous access. 3. Child has received an experimental or licensed vaccine against dengue, Zika or chikungunya at enrollment. Participants who received a dengue, Zika or CHIK vaccine after enrollment will not be excluded. 4. Child has any medical condition that would prevent them from completing a blood draw.

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Conditions

The condition(s) this trial relates to.

chikungunya dengue disease Zika virus infectious disease arbovirus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dengue fever

Contacts and locations

Locations

  • Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Department of Biochemistry and Immunology

    Belo Horizonte, Minas Gerais, 31275-030, Brazil

More trials for these conditions

Other studies related to the condition(s) this trial covers.