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Should vasopressor dosing be based on weight? new study investigates

NCT ID NCT04153578

Knowledge-focused Sponsor: Methodist Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 945 patients with septic shock to compare two ways of dosing vasopressors (medicines that raise blood pressure): one based on the patient's weight, and one not. The goal was to see which approach leads to better outcomes and fewer side effects, especially in obese patients. The study measured total vasopressor exposure over 48 hours and tracked complications like death, arrhythmia, and blood clots.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vasopressors (norepinephrine, epinephrine, phenylephrine, dopamine)
What this could lead to
If this study shows a clear benefit of one dosing strategy, it could help hospitals adopt safer, more effective vasopressor dosing for septic shock patients, especially those who are obese.
What could go wrong
This is an observational comparison, not a randomized trial, so it cannot prove cause and effect. Results may not apply to all hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

945 people

The number who actually took part.

Started

Nov 2019

Finished

Jun 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted to MDMC and MCMC from 4/1/2017-8/31/2019 will be identified through the electronic medical record utilizing ICD codes for sepsis and septic shock.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ICU admission * Medical admission type * Received NE, epinephrine (EPI), phenylephrine (PE), or dopamine (DA) for septic shock * Received NE/EPI/PE/DA for \> 24 hours * Age ≥ 18 years Exclusion Criteria: * Non-sepsis indication for vasopressors * Surgical or trauma admission type * ICU length of stay \< 24 hours * Pregnant

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Conditions

The condition(s) this trial relates to.

Body Weight toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Septic shock Weight, body

Contacts and locations

Locations

  • Methodist Dallas Medical Center

    Dallas, Texas, 75203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.