Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Water-Assisted scope may improve colon polyp removal

NCT ID NCT07040020

Disease control Sponsor: Istituto Clinico Humanitas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tested a new method called underwater ESD for removing large, flat colon polyps. Instead of using gas to inflate the colon, doctors fill it with saline water. The goal was to see if this reduces complications like bleeding or perforation and improves complete removal. 122 adults with polyps larger than 20mm took part. The study compared the underwater approach to the standard gas-based technique.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Underwater ESD (U-ESD) procedure
What this could lead to
If successful, this could make removing large colon polyps safer and more effective, reducing the need for surgery.
What could go wrong
This is a completed trial with 122 participants, so results are limited in size. The underwater technique may not prove superior for all polyp types or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

122 people

The number who actually took part.

Started

Mar 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * all patients ≥ 18 years of age with indication of ESD for large (\>20mm) nonpedunculated colorectal polyps * patients who were able to give informed written consent Exclusion Criteria: * Suspicion of deep submucosal cancer by analysis of pit pattern (KUDO Vn) * Suspicion of serrated/hyperplastic polyps by analysis of pit pattern (Kudo IIo) * Polyp involving the appendix deeply (type 2 or 3 according to Toyonaga classification) * Polyp involving the anal verge * Polyp inside the ileo-cecal valvula

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Large nonpedunculated colorectal polyps are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

polyp of large intestine precancerous condition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Precancerous lesions

Contacts and locations

Locations

  • IRCCS Humanitas Research Hospital

    Rozzano, MI, 26900, Italy