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MS walking fatigue: brain scans reveal clues to why patients slow down

NCT ID NCT06672484

Knowledge-focused Sponsor: Hasselt University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study examines walking fatigue in people with multiple sclerosis (MS) and healthy volunteers. Researchers will measure gait patterns and brain activity using wearable sensors and a brain imaging technique called fNIRS during walking tests. The goal is to understand how the brain controls walking when fatigue sets in, which may help design better therapies. The study involves 70 people with MS and 30 healthy controls, and does not test any drug or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify different walking fatigue patterns in MS, potentially guiding future therapies or rehabilitation strategies.
What could go wrong
This is an observational study, not a treatment trial. It aims to gather knowledge, not test a cure or therapy. Results may not directly lead to new treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from the Flemish MS rehabilitation centers Melsbroek (NMSC) and Overpelt (Noorderhart RMSC), as well as the REVAL research center in UHasselt. Information flyers will be distributed in the centers and via information placed on the website and social media of REVAL and the Flemish MS society. We will search age and sex-matching subjects for the healthy controls, considering a 5-year range per subject.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (part A and B): * age between 18 and 65 years old * a diagnosis of MS (2017 revisions of the McDonalds criteria) with EDSS 1 up to 6.5 (part A) and with EDSS 1 up to 5.5 (part B) OR minimal punctuation of 2 in the MSWS-12 for one of the items: 7, 10, 11, and 12 (for pwMS) * no relapses 1 month preceding the start of the study (for pwMS) * ability to walk for 6 minutes without rest Exclusion Criteria (Part A and B): * Cognitive impairment hindering understanding of study instructions, * Pregnancy * Musculoskeletal disorders in the lower limbs that are not related to MS. * PwMS needing an assistive device to walk can not be included in part B given safety reasons.

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Conditions

The condition(s) this trial relates to.

Fatigue multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Multiple sclerosis

Contacts and locations

Locations

  • National MS Melsbroek

    Melsbroek, 1820, Belgium

  • Noorderhart Rehabilitation & MS centre

    Overpelt, 3900, Belgium

  • University of Hasselt

    Diepenbeek, Limburg, 3500, Belgium

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