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Smart pain pump could stop Opioid-Induced breathing trouble

NCT ID NCT02804022

Disease control Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests a new pain relief system for women after surgery. The system delivers morphine through an IV, but it uses a smart algorithm that watches oxygen levels, breathing, and heart rate in real time. If these vital signs show a problem, the pump can adjust the pain medication to help prevent respiratory depression. The study will see if this approach reduces dangerous drops in breathing or heart rate while still controlling pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A device that delivers morphine through an IV, with an algorithm that adjusts dosing based on continuous monitoring of oxygen, breathing, and heart rate.
What this could lead to
If successful, this could lead to a safer way to manage post-surgical pain, reducing the risk of respiratory depression in patients receiving opioids.
What could go wrong
This is a small early-phase trial, so results may not apply broadly. The device's safety and effectiveness are still unproven, and there are inherent risks with opioid use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

20 people

The number who actually took part.

Started

Dec 2016

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 70 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 21-70 years old, female * Healthy participants who are American Society of Anesthesiologists physical status 1 and 2 (with well controlled medical problems) * Undergoing elective surgery with the intent of using postoperative PCA with morphine for postoperative analgesia Exclusion Criteria: * Allergy to morphine * With significant respiratory disease and obstructive sleep apnea * Unwilling to place oxygen saturation monitoring devices during study period * Unable to comprehend the use of patient controlled analgesia * Pregnant

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory depression

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.