Brain Wave-Guided nerve stimulation may tame Drug-Resistant epilepsy
NCT ID NCT04693221
First seen Feb 11, 2026 · Last updated Jun 23, 2026 · Updated 22 times
Summary
This study tests whether fine-tuning a vagal nerve stimulator (VNS) using a brain wave measure called phase lag index (PLI) can better reduce seizures in people with epilepsy that doesn't respond to medication. About 140 participants who already have a VNS device will have their settings chosen either by the PLI method or randomly. The goal is to see if the PLI-guided settings lead to fewer seizures per month.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Clinical neurophysiology, CHU Dijon
Dijon, France, 21079, France
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Clinical neurophysiology, CHU Lille
Lille, France, 59037, France
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Department of clinical neurophysiology, Hôpital La Timone, APHM
Marseille, France, 13885, France
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Department of functional explorations of the nervous system, CHU
Amiens, France, 80054, France
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Epilepsy neurophysiopathology department, CHU Grenoble
Grenoble, France, 38043, France
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Epileptology Department, CHU Rennes
Rennes, France, 35000, France
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HCL Lyon
Lyon, France, 69003, France
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Hôpital St Joseph St Luc
Lyon, FRA, 69007, France
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Neurology Department, CHU Bordeaux
Bordeaux, France, 33000, France
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Neurology Department, CHU Strasbourg
Strasbourg, France, 67098, France
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Neurology and clinical neurophysiology, CHU Bretonneau
Tours, France, 37044, France
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Neuropediatrics department, CHU Angers
Angers, France, 49933, France
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Neurophysiological explorations, Hôpital Pierre Paul Riquet, Purpan
Toulouse, France, 31059, France
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Neurophysiology Department
Paris, France, 75014, France
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Neurophysiology Department, CHU Rouen
Rouen, France, 76000, France
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Neurosurgery Department, APHP
Paris, France, 75013, France
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Neurosurgery Department, CHRU Nancy
Nancy, France, 54000, France
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Neurosurgery Department, CHU Nantes
Nantes, France, 44093, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vagal nerve stimulation (VNS) device
What this could lead to
If successful, this could provide a more effective way to set VNS devices, helping more patients with drug-resistant epilepsy have fewer seizures.
What could go wrong
This is a mid-stage study with 140 participants, and the approach is still experimental. It may not work better than standard settings, and individual responses can vary.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.