Vitamin k supplement may ease knee arthritis – early trial underway
NCT ID NCT05505552
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 36 times
Summary
This pilot study tests whether taking a daily vitamin K supplement for 6 months can improve leg function in adults aged 50 and older with mild to moderate knee osteoarthritis. The study includes 37 participants with low vitamin K levels. It is a small, early-stage trial designed to gather information for a larger study, not to prove that vitamin K works as a treatment.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Tufts University
Boston, Massachusetts, 02111, United States
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UMass Memorial Medical Center
Worcester, Massachusetts, 01605, United States
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University of North Carolina Chapel Hill
Chapel Hill, North Carolina, 27599, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin K (phylloquinone) supplement
What this could lead to
If it works, this could point toward a simple, low-cost supplement to help maintain mobility in people with knee osteoarthritis.
What could go wrong
This is a very small pilot study with only 37 participants, designed mainly to gather data for a larger trial. It is not yet testing whether vitamin K actually improves symptoms, so results may not lead to any practical benefit.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.