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Vitamin k supplement shows promise for knee arthritis in early trial

NCT ID NCT05505552

Symptom relief Sponsor: Tufts University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tests whether taking a daily vitamin K supplement can improve leg function in adults with mild to moderate knee osteoarthritis. Researchers will give 37 participants either vitamin K or a placebo for 6 months. The main goal is to gather information needed to design a larger, more definitive study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin K (phylloquinone)
What this could lead to
If it works, this could point toward a simple, low-cost supplement to help maintain mobility in people with knee osteoarthritis.
What could go wrong
This is a very small pilot study with only 37 participants, designed mainly to gather data for a future larger trial. It is not designed to prove that vitamin K works, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

37 people

The number who actually took part.

Started

Sep 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 50 years * Male or post-menopausal female (no menses in the last year) * Plasma phylloquinone \<1.0 nmol/L * Chronic knee discomfort based on affirmative response to the question "During the past 12 months, have you had pain, aching, or stiffness in or around your knee(s) on most days for at least one month?" * Kellgren-Lawrence (KL) grade 2-3 in at least one knee * Ability to understand study procedures and to comply with them for the entire length of the study * Ability to answer questions by phone * Ability to swallow capsules Exclusion Criteria: * KL grade 4 in at least one knee * Inability to walk * Cognitive impairment (based on a Montreal Cognitive Assessment Test score ≤ 17) * Widespread pain * Malabsorption disorders (e.g. advance liver disease, stage 4 or 5 chronic renal disease, Crohn's disease, celiac sprue) * Serious medical conditions or impairments that, in the view of the investigator, would obstruct study participation * Plan to permanently relocate from the greater Boston, MA or Chapel Hill NC areas during the trial period * Planned knee or hip arthroplasty during the study period * Undergoing cancer treatment * \< 50 years old * Circulating phylloquinone ≥ 1.0 nmol/L * Warfarin (Jantoven) use * Use of other investigational drugs * Use of herbal, botanical or vitamin K supplements * Use of assistive walking devices

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteo arthritis knee

Contacts and locations

Locations

  • Tufts University

    Boston, Massachusetts, 02111, United States

  • UMass Memorial Medical Center

    Worcester, Massachusetts, 01605, United States

  • University of North Carolina Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

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