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Vitamin D3 may tame asthma in overweight teens

NCT ID NCT05431920

Disease control Sponsor: Hospital Infantil de Mexico Federico Gomez Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether vitamin D3 supplements can improve asthma control in adolescents aged 12-17 who have obesity, non-allergic asthma, and vitamin D deficiency. Participants receive either a high or standard daily dose of vitamin D3 for three months. Researchers will measure asthma symptoms, lung function, and asthma attack rates to see if supplementation helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D3 (oral supplement)
What this could lead to
If it works, this could point toward a simple, low-cost vitamin D supplement to help control asthma in teens with obesity and vitamin D deficiency.
What could go wrong
This is a small, early-stage trial with only 264 participants. Results may not apply to all teens, and high-dose vitamin D can cause side effects like kidney stones or high calcium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 264 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adolescents of 12 to 17 years old. * Diagnosis of exogen obesity with a body mass index (BMI) greater than percentile 95 for age and sex, according to the Center for Disease Control and Prevention (CDC) graphics, that precedes the diagnosis of asthma. * Plasmatic concentration of 25-hydroxyvitamin D less than 30 ng/ml at screening visit based on local laboratory test. * Physician-diagnosed asthma, with more than 6 months of evolution, based on medical history, physical examination, clinical criteria according to the Global Initiative For Asthma 2020 (GINA) and confirmed with a spirometry with reversibility after the administration of a bronchodilator. * Asthma severity (intermittent or mild persistent or moderate persistent) according to the National Asthma Education and Prevention Program (NAEPP) and classified as controlled, partly controlled or uncontrolled according to GINA 2020. * Negative allergic skin tests. Exclusion Criteria: * History of systemic or chronic degenerative disease (renal, pulmonar, cardiovascular, infectious, muscular, immunological, hypertension, diabetes mellitus, cancer, nonalcoholic fatty liver disease). * Current treatment with immunomodulators or immunostimulants, up to 6 months before the intervention. * History of adverse effects to vitamin D. * Treatment with oral steroids 3 months previous to the enrollment. * Active smoking. Elimination criteria: * Parents, tutors, legal guardians or participants that decide to withdraw from the study any time. * Pregnancy during study. * Severe adverse effects to vitamin D.

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Conditions

The condition(s) this trial relates to.

asthma intrinsic asthma Obesity obesity disorder vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-allergic asthma Obesity Vitamin D deficiency

Contacts and locations

Locations

  • Hospital Infantil de México Federico Gómez

    Mexico City, Mexico City, 06720, Mexico

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