Vitamin c may boost pain tolerance, small study suggests
NCT ID NCT06971315
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested whether high-dose vitamin C can raise how much pressure people can detect or tolerate before feeling pain. Thirty-eight healthy adults took either vitamin C or a placebo over 24 hours. Researchers measured pain thresholds using a device that applies pressure. The goal is to find a safe, non-drug option for acute pain relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin C (dietary supplement)
- What this could lead to
- If vitamin C proves effective, it could offer a simple, low-cost option for managing acute pain without opioids or NSAIDs.
- What could go wrong
- This is a small, early-stage trial in healthy volunteers, not people in pain. Results may not apply to real-world acute pain, and high doses may cause side effects like stomach upset.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
38 people
The number who actually took part.
- Started
-
Jul 2025
- Finished
-
Dec 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 to 65 years old; 2. No acute or chronic pain; 3. No pain medication; 4. French or English-speaking Exclusion Criteria: 1. Currently using vitamin C supplements; 2. Pain in the last week or active cancer; 3. Unavailable for follow-up; 4. Allergy to milk (lactose in the placebo), or vitamin C, 5. Treated with cyclosporine or warfarin (interaction with vitamin C); 6. Pre-existing oxalate nephropathy, liver cirrhosis or hemochromatosis; 7. Evidence of joint or overlying skin infection in the areas of testing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, H4J 1C5, Canada
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Other studies related to the condition(s) this trial covers.
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