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Could vitamin c deficiency be fueling childhood diarrhea?

NCT ID NCT05328037

Knowledge-focused Sponsor: Institut Pasteur Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examined 288 children aged 2 to 5 in France, Africa, and South America to see if low vitamin C levels are more common in those with diarrhea. Researchers compared vitamin C in the blood of children with diarrhea to healthy children of the same age and sex. The goal is to understand if vitamin C deficiency is a risk factor, which could help improve prevention strategies in high-risk areas.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it works, this could point toward better nutritional guidelines to prevent diarrhea in young children.
What could go wrong
This is an observational study, not a treatment trial. It only looks for a link, not a cause, and results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

288 people

The number who actually took part.

Started

Apr 2022

Finished

Mar 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population is children aged 18 months to 5 years (60 months) in metropolitan France, Central African Republic, and South America. Control subjects will be included in the hospital when they come for consultation for reasons other than diarrhea. Children suffering from acute or chronic diarrhea will be included in the hospital during a consultation.

Ages

18 to 60 months

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Controls : Inclusion Criteria: * not suffering of diarrhea * no fever * no sign of infection Exclusion criteria : * Suspected or diagnosed infectious diseases * Known genetic diseases * Known diseases that may interfere with iron and/or vitamin C metabolism * Known inflammatory diseases * Malnutrition * Diarrhea * Fever * Positive malaria rapid diagnostic test (Africa) * Child currently being breastfed Chronic diarrhea cases : Inclusion Criteria: -Children suffering from chronic diarrhea defined by the emission of at least 3 soft or liquid stools per day for at least 4 weeks. Exclusion criteria : * Suspected or diagnosed infectious diseases * Known genetic diseases * Known diseases that may interfere with iron and/or vitamin C metabolism * Known inflammatory diseases * Positive malaria rapid diagnostic test (Africa) * Antibiotic treatment prescribed within 10 days prior to sampling * Nutritional supplements in the three months prior to sampling * Vitamin C supplementation in the last 3 months prior to blood collection * Child currently being breastfed Acute diarrhea cases : Inclusion Criteria: -Children suffering from acute diarrhea defined as 3 or more loose or watery stools per day for at least 3 consecutive days and up to 10 consecutive days. Exclusion criteria : * Malnutrition * Suspected or diagnosed infectious diseases * Known genetic diseases * Known diseases that may interfere with iron and/or vitamin C metabolism * Known inflammatory diseases * Positive malaria rapid diagnostic test (Africa) * Antibiotic treatment prescribed within 10 days prior to sampling * Nutritional supplements in the three months prior to sampling * Vitamin C supplementation in the last 3 months prior to blood collection * Child currently being breastfed

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Conditions

The condition(s) this trial relates to.

acute diarrhea chronic diarrheal disease diarrheal disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diarrhea Infantile

Contacts and locations

Locations

  • Centre Hospitalier Territorial Gaston Bourret

    Noumea, New Caledonia

  • Complexe Pédiatrique

    Bangui, Central African Republic

  • Hopital Necker

    Paris, 75015, France

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