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Brain-Wash breakthrough? new trial takes on deadly ventriculitis

NCT ID NCT06358209

Disease control Sponsor: RenJi Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This study tests whether washing out infected fluid from the brain's cavities (ventricular irrigation) can improve survival and recovery in people with severe ventriculitis, a life-threatening brain infection. About 310 adults aged 18-65 with confirmed ventriculitis will be randomly assigned to receive either standard antibiotic treatment or standard treatment plus ventricular irrigation. The goal is to see if the irrigation procedure leads to higher cure rates and fewer long-term problems like brain damage or epilepsy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 310 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 years old; * CSF is purulent (it appears cloudy or yellow) and white blood cell count over 1000×10\^6/L. * Fever (\>38.0°C) * Meet at least one of the following: 1. Patient has organism(s) identified from CSF by a culture or non-culture based microbiologic testing method; 2. Cranial CT or MRI indicating intraventricular floccule or pus. * With consent form Exclusion Criteria: * With GCS score of 3 * With unstable vital signs such as no spontaneous breathing and blood pressure maintenance drugs * With severe propensity for bleeding (Such as coagulation dysfunction, active bleeding, etc.), and unable to tolerate the surgical procedures or operations related to ventricular irrigation treatment. * Pregnant or lactating women

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Conditions

The condition(s) this trial relates to.

central nervous system infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Central nervous system infections

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    35 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 904 Hospital of the People's Liberation Army Joint Logistic Support Force

    NOT_YET_RECRUITING

    Wuxi, Jiangsu, China

  • Affiliated Hospital of Nantong University

    NOT_YET_RECRUITING

    Nantong, Jiangsu, China

  • Affiliated Hospital of Yangzhou University

    NOT_YET_RECRUITING

    Yangzhou, Jiangsu, China

  • First Affiliated Hospital of Zhejiang University

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, China

  • Ganzhou People's Hospital

    NOT_YET_RECRUITING

    Ganzhou, Jiangxi, China

  • Henan Provincial People's Hospital

    NOT_YET_RECRUITING

    Zhengzhou, Henan, China

  • Inner Mongolia People's Hospital

    NOT_YET_RECRUITING

    Hohhot, The Nei Monggol Autonomous Region, China

  • Jiangsu Province Hospital

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, China

  • Nanfang Hospital, Southern Medical University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

  • Nanjing Drum Tower Hospital

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, China

  • Qilu Hospital of Shandong University

    NOT_YET_RECRUITING

    Jinan, Shandong, China

  • Renji Hospital, School of Medicine, Shanghai Jiaotong University

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Shanghai Donglei Brain Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Shanghai East Hospital

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, China

  • Shanghai Tenth People's Hospital

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, China

  • Shenzhen Second People's Hospital

    NOT_YET_RECRUITING

    Shenzhen, Guangdong, China

  • South taihu hospital affiliated to huzhou college

    RECRUITING

    Huzhou, Zhejiang, China

  • The First Affiliated Hospital of Fujian Medical University

    NOT_YET_RECRUITING

    Fuzhou, Fujian, China

  • The First Affiliated Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, Heilongjiang, China

  • The First Affiliated Hospital of Soochow University

    NOT_YET_RECRUITING

    Suzhou, Jiangsu, China

  • The First Affiliated Hospital of University of Science and Technology of China

    NOT_YET_RECRUITING

    Hefei, Anhui, China

  • The First Affiliated Hospital of Wannan Medical College

    NOT_YET_RECRUITING

    Wuhu, Anhui, China

  • The First Affiliated Hospital of Xinjiang Medical University

    NOT_YET_RECRUITING

    Ürümqi, Xinjiang Uygur Autonomous Region, China

  • The Fourth Affiliated Hospital of China Medical University

    NOT_YET_RECRUITING

    Shenyang, Liaoning, China

  • The Second Affiliated Hospital of Air Force Medical University

    NOT_YET_RECRUITING

    Xi'an, Shaanxi, China

  • The Second Affiliated Hospital of Nanchang University

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, China

  • The Second Affiliated Hospital of Naval Medical University

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, China

  • The Second People's Hospital of Anhui Province

    NOT_YET_RECRUITING

    Hefei, Anhui, China

  • The affiliated people's hospital of ningbo university

    NOT_YET_RECRUITING

    Ningbo, Zhejiang, China

  • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology

    RECRUITING

    Wuhan, Hubei, China

  • West China Hospital, Sichuan University

    NOT_YET_RECRUITING

    Chengdu, Sichuan, China

  • Xiangya Hospital of Central South University

    NOT_YET_RECRUITING

    Changsha, Hunan, China

  • Xuanwu Hospital Capital Medical University

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, China

  • Zhongshan Hospital of Traditional Chinese Medicine

    NOT_YET_RECRUITING

    Zhongshan, Guangdong, China

  • Zhujiang Hospital of Southern Medical University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, China

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Other studies related to the condition(s) this trial covers.